… pluripotency in vivo [192]. Mouse ESCs are in an unstable balance between pluripotency
and differentiation … (maintained by LIF) or promote differentiation (induced by FGF). However, …

… noncoding RNA (lncRNA) genome function in cell differentiation is lacking. Using CRISPR
interference (CRISPRi) in human induced pluripotent stem cells, we performed dual genome-…

… controlling pluripotent maintenance and induction, and to model neurodegenerative diseases
with pluripotent … -dependent lincRNAs, we included lincRNA transcriptional units nearest to …

… Oplr16 in pluripotency, we collected cells at different days during embryoid body differentiation.
… positively associated with the status of pluripotency, sharing a similar expression pattern …

… Nanog was stained to show pluripotent differences between Peblr20 down-regulated iPSCs
and normal iPSCs. Single colonies (SCs) were selected and cultured for expansion. Cells …

… p53 during differentiation. In contrast, lincRNA-p21 is induced by p53 and prevents
reprogramming by building a scaffold for histone and DNA methyltransferases at pluripotency genes. …

… pluripotency, described as the ability to generate all somatic and germline lineages of the
embryo [16,17]. The pluripotency is a circuit … fluctuating levels of the pluripotency TFs as well as …

… in Carma-depleted ESCs, supporting the importance of the Carma–miR-133a2 to Notch–repressor
lincRNAs axis in controlling the cardiogenic fate of differentiating precursors. …

… From our assays and analyses herewith, we conclude that Mrhl majorly acts to regulate
differentiation and development related genes and processes in mESCs. Also, we compared the …

Although long non-coding RNAs (lncRNAs) is one of the most abundant classes of RNAs
encoded within the mammalian genome and are highly expressed in the adult brain, they …