[HTML][HTML] Toward a mechanistic understanding of DNA methylation readout by transcription factors
… base locally modifies the structural features of DNA in … of DNA bases, the most prevalent of
which is DNA methylation, is an … In prokaryotes, methylation of adenines is used as part of the …
which is DNA methylation, is an … In prokaryotes, methylation of adenines is used as part of the …
[HTML][HTML] DNA demethylases remodel DNA methylation in rice gametes and zygote and are required for reproduction
… We found that DNA methylation is locally reconfigured after fertilization and is intensified
during embryogenesis. Genetic, epigenomic, and transcriptomic analysis revealed that three …
during embryogenesis. Genetic, epigenomic, and transcriptomic analysis revealed that three …
[HTML][HTML] DNA methylation: Precise modulation of chromatin structure and dynamics
… It should be noted that the magnitude of effects caused by CpG methylation strongly
depends on the local DNA sequence context around the methylated site [19]. For example, an …
depends on the local DNA sequence context around the methylated site [19]. For example, an …
[HTML][HTML] Comprehensive analysis of DNA methylation and prediction of response to neoadjuvanttherapy in locally advanced rectal cancer
… DNA methylation markers predictive of pCR in LARC patients treated with nCRT. We used
high-throughput DNA methylation … The methylation levels of the selected CpGs confirmed the …
high-throughput DNA methylation … The methylation levels of the selected CpGs confirmed the …
Deciphering the genetic code of DNA methylation
… The molecular mechanisms described above have laid the foundation for many studies that
use genetic features to predict local DNA methylation. These studies have shed light on the …
use genetic features to predict local DNA methylation. These studies have shed light on the …
Quantitative comparison of within-sample heterogeneity scores for DNA methylation data
… local deep amplicon sequencing can be used to reconstruct the probability distribution of
DNA methylation … the concept of locally disordered DNA methylation patterns (24) to quantify …
DNA methylation … the concept of locally disordered DNA methylation patterns (24) to quantify …
[HTML][HTML] A genome-scale map of DNA methylation turnover identifies site-specific dependencies of DNMT and TET activity
PA Ginno, D Gaidatzis, A Feldmann, L Hoerner… - Nature …, 2020 - nature.com
… Local levels of DNA methylation result from opposing enzymatic activities, the rates of
which remain largely unknown. Here we developed a theoretical and experimental framework …
which remain largely unknown. Here we developed a theoretical and experimental framework …
Natural variation in DNA methylation homeostasis and the emergence of epialleles
… By examining variation in DNA methylation among hundreds … that robust targeting of DNA
methylation to heterochromatin is … of methylation in heterochromatin had more genes with DNA …
methylation to heterochromatin is … of methylation in heterochromatin had more genes with DNA …
[HTML][HTML] The immune factors driving DNA methylation variation in human blood
J Bergstedt, SAK Azzou, K Tsuo, A Jaquaniello… - Nature …, 2022 - nature.com
… , local DNA sequence variation is the strongest predictor in 99.2% of cases (Fig. 5c and
Supplementary Data 7). Local genetic variation explains >25% of DNA methylation variance at …
Supplementary Data 7). Local genetic variation explains >25% of DNA methylation variance at …
[HTML][HTML] DNA methylation: a historical perspective
AL Mattei, N Bailly, A Meissner - Trends in Genetics, 2022 - cell.com
… rapidly growing number of base-resolution methylation maps. Despite this, several … of DNA
methylation patterns remain under investigation. Here, we review the field of DNA methylation …
methylation patterns remain under investigation. Here, we review the field of DNA methylation …
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