[HTML][HTML] An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8+ T cell magnitude and short-lived differentiation status

H Takata, JL Mitchell, J Pacheco, A Pagliuzza… - Cell host & …, 2023 - cell.com
… between the HIV reservoir in CD4 + T cells and the magnitude and differentiation status
of HIV-specific CD8 + T cells, we investigated these cells from acute and chronic HIV-infected …

[HTML][HTML] Spontaneous HIV expression during suppressive ART is associated with the magnitude and function of HIV-specific CD4+ and CD8+ T cells

M Dube, O Tastet, C Dufour, G Sannier, N Brassard… - Cell Host & Microbe, 2023 - cell.com
… memory T cells and CCR6- and activation-marker-expressing cells. The magnitude of the
active reservoir positively correlates with total HIV-specific CD4 + and CD8 + T cell responses …

[HTML][HTML] HIV-1 elite controllers present a high frequency of activated regulatory T and Th17 cells

DG Caetano, HHS de Paula, G Bello, B Hoagland… - PLoS …, 2020 - journals.plos.org
… observed here in patients with long-term control of infection are a signal of immune
preservation at a magnitude that is not achieved even with antiretroviral therapy, as most of our …

Modeling HIV multiple infection

T Guo, Z Qiu, K Kitagawa, S Iwami, L Rong - Journal of Theoretical Biology, 2021 - Elsevier
… containing a given number of proviruses by the total number of cells from each patient (113
cells for patient R, 103 cells for patient B), we compare with model prediction of the frequency

[HTML][HTML] The multifaceted nature of HIV latency

C Dufour, P Gantner, R Fromentin… - The Journal of clinical …, 2021 - Am Soc Clin Investig
… parts of the body at relatively high frequencies, these measures … cells (26, 27), whereas
HIV DNA quantification typically measures frequencies that are two to three orders of magnitude

An HIV stochastic model with cell-to-cell infection, B-cell immune response and distributed delay

Y Wang, J Liu, X Zhang, JM Heffernan - Journal of Mathematical Biology, 2023 - Springer
… In order to examine the influence of the white noise on the magnitude of the stochastic B-cell-activated
reproduction number, we consider four kinds of white noise intensity: (i) without …

[HTML][HTML] Estimating the contribution of CD4 T cell subset proliferation and differentiation to HIV persistence

DB Reeves, C Bacchus-Souffan, M Fitch… - Nature …, 2023 - nature.com
… Finally, by multiplying the subset frequency by the infection frequency, we derived the … In
all subsets except T N , the cellular turnover rate was roughly an order of magnitude faster than …

[HTML][HTML] HIV-specific T cell responses reflect substantive in vivo interactions with antigen despite long-term therapy

EM Stevenson, AR Ward, R Truong, AS Thomas… - JCI insight, 2021 - ncbi.nlm.nih.gov
… the magnitudes of T cell responses to the HIV Nef protein with residual frequencies of infected
cells (… The mean frequency of Nef-specific T cells on week 24 of our study was 107.7/10 6 …

[HTML][HTML] Combined single-cell transcriptional, translational, and genomic profiling reveals HIV-1 reservoir diversity

G Sannier, M Dube, C Dufour, C Richard, N Brassard… - Cell reports, 2021 - cell.com
… + T cells carrying HIV genomes are one order of magnitude … blood mononuclear cells (PBMCs)
from people living with HIV (… , we performed combined single-cell analyses of viral gene co…

Abundant HIV-infected cells in blood and tissues are rapidly cleared upon ART initiation during acute HIV infection

L Leyre, E Kroon, C Vandergeeten… - Science translational …, 2020 - science.org
… infection, we measured the frequency of cells harboring integrated HIV DNA in blood and
tissues (inguinal lymph nodes and sigmoid colon biopsies) in recently infected individuals …