… Sox11 is mainly expressed in neurogenic niches of the adult mammalian brain and its ectopic
expression promotes neuronal differentiation of NPCs [86]. In addition, in vivo conditional …

Melanin-concentrating hormone (MCH) is a small cyclic peptide expressed in all mammals,
mainly in the hypothalamus. MCH acts as a robust integrator of several physiological …

… emerged as an essential feature of the mammalian brain. Sweet and bitter evoke opposing
… Next we examined how the brain modulates this hardwired circuit to control taste behaviors. …

… drug-metabolizing enzymes within the brain endothelial cells, such as CYP 450 enzymes
(CYP1B1 and CYP2U1, CYP-3AF), results in the formation of the metabolic … mammalian brain …

… , and neurotoxins in the brain. Local brain metabolism of endogenous substrates and drugs
that cross the BBB may … In mammals, CYP enzymes are engaged in the biosynthesis and …

… to develop drugs to target it. This review will briefly describe L-tryptophan metabolism and
… In mammalian cells, most L-Trp is metabolized via the KP, while the remainder is utilized in …

… and application of biotransformation of drugs by mammalian systems, microorganisms, and
… on metabolism, and how insights gained from biotransformation studies can influence drug …

… drug penetration in brain tissues. Lastly, in addition to highlighting landmark scientific and
medical literature, we provide practical advice on formulation development, device selection, …

… From an evolutionary point of view, a comparison of glucose and oxygen metabolic rates
of the adult brain in awake mammals (rodents, macaque, baboon) suggests that the total …

… The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and migration, to …