Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy

SJ Galli, M Metz, P Starkl, T Marichal, M Tsai - Allergo journal international, 2020 - Springer
… of the venoms of six different poisonous snakes [84]. … venom or Russell’s viper venom,
which “arm” mast cells with IgE antibodies that bear specificity for components of those venoms, …

Bothrops jararacussu snake venom lectin induces mast cell activation and vascular permeability enhance in an animal model

FH Kwasniewski, AM Kayano, AN Fukunaga… - Toxicon, 2022 - Elsevier
… jararacussu snake venom, on mast cells and vasopermeability were investigated in this
study. BjcuL activates mast cells and increases vasopermeability through the involvement of …

Mast Cell and Basophil Granule Proteases - In Vivo Targets and Function

L Hellman, S Akula, Z Fu, S Wernersson - Frontiers in Immunology, 2022 - frontiersin.org
venoms from a number of snake species, indicating that tryptase is the dominant player in the
protection against snake venom (… as a potential treatment for snake bite envenoming. A few …

Pain and Cellular Migration Induced by Bothrops jararaca Venom in Mice Selected for an Acute Inflammatory Response: Involvement of Mast Cells

FV Kondo, WHK Cabrera, OG Ribeiro… - Frontiers in …, 2022 - frontiersin.org
… isolated from the venom of the Bothrops pirajaí snake, and observed induction of … venom
injection induces chemotaxis (37), which can be regulated by mediators released by mast cells

IgE antibodies increase honeybee venom responsiveness and detoxification efficiency of mast cells

P Starkl, N Gaudenzio, T Marichal, LL Reber… - Allergy, 2022 - Wiley Online Library
Background In contrast to their clearly defined roles in allergic diseases, the physiologic
functions of Immunoglobulin E antibodies (IgEs) and mast cells (MCs) remain enigmatic. Recent …

Cobrotoxin, a single peptide from snake venom, ameliorates atopic dermatitis via suppression of MK2 modulated by IgE and IL-33

JW Lee, Y Choi, SH Lee, NJ Park… - Molecular & Cellular …, 2024 - Springer
… In a DNCB-induced AD mouse model, CoTX treatment significantly improved AD symptoms
and reduced epidermal thickness and mast cell infiltration. Finally, CoTX lowered serum IgE …

Mast Cells Modulate the Immune Response and Redox Status of the Gastrointestinal Tract in Induced Venom Pathogenesis

N Zerarka-Chabane, F Laraba-Djebari… - Inflammation, 2022 - Springer
… Indeed, several investigations reported that MCs express on their surface many receptors
that interact with components of venoms (bee, spider, and snake) and neuropeptide …

Mast cells in inflammation and disease: recent progress and ongoing concerns

SJ Galli, N Gaudenzio, M Tsai - Annual review of immunology, 2020 - annualreviews.org
… in host defense, ie, promoting resistance to certain venoms, has also been supported both
by work in mast cell–engrafted WBB6F1-Kit W/Wv and C57BL/6-Kit W-sh/W-sh mice and by …

Effect of animal venom toxins on the main links of the homeostasis of mammals

R Matkivska, I Samborska… - Biomedical …, 2023 - spandidos-publications.com
… Toxins of scorpion and snake venoms selectively change the activity of such channels (105-112).
Experimental studies have demonstrated that dendrotoxins produced by several …

Venom components with other important biological activities

D Mebs - Handbook of Toxinology, 2020 - taylorfrancis.com
… Examples Include enzymes like kalllkreins, components of lizard and snake venoms, which
… Well-studied toxins such as the mast cell degranulating peptide from bee venom have …