Traumatic brain injury: mechanistic insight on pathophysiology and potential therapeutic targets
… The current review gives a brief outline of the pathophysiological mechanism of TBI and
various biochemical pathways involved in brain injury, pharmacological treatment approaches, …
various biochemical pathways involved in brain injury, pharmacological treatment approaches, …
Mechanism of non‐contact ACL injury: OREF Clinical Research Award 2021
BP Boden, FT Sheehan - Journal of Orthopaedic Research®, 2022 - Wiley Online Library
… , understanding the mechanism of ACL injury was limited. … to uncovering the mechanism of
noncontact ACL injury (NC-ACLI) … of ACL injury events revealed most (70%) injuries involve …
noncontact ACL injury (NC-ACLI) … of ACL injury events revealed most (70%) injuries involve …
[HTML][HTML] Mechanistic insights and perspectives involved in neuroprotective action of quercetin
… However, the exact mechanism of action is still mystery and similarly there are a number
of hypothesis exploring the mechanism of neuroprotection. Quercetin enhances neuronal …
of hypothesis exploring the mechanism of neuroprotection. Quercetin enhances neuronal …
Achilles tendon rupture: mechanisms of injury, principles of rehabilitation and return to play
… Therefore, the aim of this narrative review is to give an insight into the mechanism of injuries
… The aim of this narrative review is to give an insight into the mechanism of injuries of an ATR…
… The aim of this narrative review is to give an insight into the mechanism of injuries of an ATR…
Dualistic roles and mechanistic insights of macrophage migration inhibitory factor in brain injury and neurodegenerative diseases
W Xuan, W Xie, F Li, D Huang, Z Zhu… - Journal of Cerebral …, 2023 - journals.sagepub.com
… In this review, we highlight the novel findings of MIF mechanistic insights in immune cells
participating in acute and chronic brain disorders, which may shed light on MIF as a …
participating in acute and chronic brain disorders, which may shed light on MIF as a …
Traumatic brain injury: mechanisms of glial response
… In this regard, the increase expression in GLT-1 by ceftriaxone reduce post-traumatic
seizures and gliosis (Goodrich et al., 2013). The mechanism by which ceftriaxone induce the …
seizures and gliosis (Goodrich et al., 2013). The mechanism by which ceftriaxone induce the …
Beyond the brain: peripheral interactions after traumatic brain injury
… One mechanism driving development of acute kidney injury post-TBI is the aforementioned
increase in SNS activity. The increased SNS activation results in reduced renal glomerular …
increase in SNS activity. The increased SNS activation results in reduced renal glomerular …
[HTML][HTML] Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis
AC Bolte, AB Dutta, ME Hurt, I Smirnov… - Nature …, 2020 - nature.com
… We find that TBI results in compromised meningeal lymphatic drainage that can last out to
at least one month post-injury. Mechanistically, we report that increased intracranial pressure (…
at least one month post-injury. Mechanistically, we report that increased intracranial pressure (…
Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement
AL Kalinski, C Yoon, LD Huffman, PC Duncker… - elife, 2020 - elifesciences.org
Sciatic nerve crush injury triggers sterile inflammation within the distal nerve and axotomized
dorsal root ganglia (DRGs). Granulocytes and pro-inflammatory Ly6C high monocytes …
dorsal root ganglia (DRGs). Granulocytes and pro-inflammatory Ly6C high monocytes …
Autophagy and ALS: mechanistic insights and therapeutic implications
JP Chua, H De Calbiac, E Kabashi, SJ Barmada - Autophagy, 2022 - Taylor & Francis
… These observations suggest that oligodendrocyte autophagy may play a necessary but
insufficient role in post-injury repair of the spinal cord [Citation453], but excessive autophagy in …
insufficient role in post-injury repair of the spinal cord [Citation453], but excessive autophagy in …
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