[HTML][HTML] The allopregnanolone response to acute stress in females: preclinical and clinical studies

MG Pisu, L Concas, C Siddi, M Serra, P Porcu - Biomolecules, 2022 - mdpi.com
… has been reported in female C57BL/6 mice at the onset of puberty [69]; however, to the
best of our knowledge, allopregnanolone levels in response to acute stress have not yet been …

[HTML][HTML] Allopregnanolone is associated with a stress-induced reduction of heart rate variability in premenstrual dysphoric disorder

A Hamidovic, J Davis, F Soumare, A Naveed… - Journal of Clinical …, 2023 - mdpi.com
… that stress-induced HF-HRV reduction in women with PMDD is mediated by their baseline
allopregnanolone level, … rate during stress and allopregnanolone underlies PMDD expression. …

[HTML][HTML] Allopregnanolone in premenstrual dysphoric disorder (PMDD): Evidence for dysregulated sensitivity to GABA-A receptor modulating neuroactive steroids …

L Hantsoo, CN Epperson - Neurobiology of Stress, 2020 - Elsevier
… ; the GABA A -R in PMDD is unable to adapt its composition to changing ALLO levels across
the menstrual cycle, resulting in affective symptoms and poor regulation of stress response. …

[HTML][HTML] The role of allopregnanolone in depressive-like behaviors: Focus on neurotrophic proteins

FB Almeida, MS Nin, HMT Barros - Neurobiology of Stress, 2020 - Elsevier
… decrease in allopregnanolone levels in limbic brain areas in rodents submitted to stress-induced
models of depression, such as social isolation and chronic unpredictable stress. Further…

Allopregnanolone in mood disorders: Mechanism and therapeutic development

S Chen, L Gao, X Li, Y Ye - Pharmacological Research, 2021 - Elsevier
… might regulate dopamine level during both acute and chronic stress. The administration of
… anxious-like behaviors and raised endogenous ALLO level in mice brain. The application of …

[HTML][HTML] Pleiotropic actions of allopregnanolone underlie therapeutic benefits in stress-related disease

G Boero, P Porcu, AL Morrow - Neurobiology of stress, 2020 - Elsevier
… cortisol and suppression of the HPA axis response to stress. Considering the ability of
allopregnanolone to regulate the HPA axis at the level of the hypothalamus, it is possible that …

Allopregnanolone: The missing link to explain the effects of stress on tic exacerbation?

M Bortolato, BJ Coffey, V Gabbay… - Journal of …, 2022 - Wiley Online Library
… Our results showed that, in this model, acute stress led to a generalised enhancement of
the levels of progesterone, DHP and AP in the PFC. We investigated the systemic effects of …

[HTML][HTML] Allopregnanolone, the neuromodulator turned therapeutic agent: thank you, next?

G Pinna - Frontiers in endocrinology, 2020 - frontiersin.org
… the stress—induced decrease of allopregnanolone in rodent brain as well as its lower …
question is whether allopregnanolone biosynthesis (allopregnanolone levels and expression of …

Decreased serum allopregnanolone and progesterone levels in male patients with bipolar disorder and their effects on cognitive functions

M Karademir, E Beyazyüz, M Beyazyüz… - European Archives of …, 2024 - Springer
… and healthy controls, it was observed that allopregnanolone levels in the PFC were lower in
… lower allopregnanolone levels than controls and the decrease in allopregnanolone levels

Allopregnanolone and depression and anxiety symptoms across the peripartum: an exploratory study

LR Standeven, LM Osborne, JF Betz… - … of women's mental …, 2022 - Springer
… We hypothesized that ALLO levels would be inversely correlated with anxiety and … affect
ALLO levels and thus could have affected our results, including medical conditions, levels of …