… However, how these alterations reverberate on cortical activity … of migraine, herein we
investigated the effects of FHM1-driven synaptic alterations in the visual cortex of awake mice. …

… by investigating the cortical feedback inhibition microcircuit … INs) in a mouse model of a
rare monogenic migraine. Despite … synaptic transmission at cortical L2/3 SOM INs synapses is …

… Considering the large fraction of the NMDAR EPSC which is inhibited by a higher concentration
of Ro25 (20 uM) in our juvenile WT mice, the synaptic NMDARs that are activated in L2/…

… We propose that long-term plasticity of synaptic transmission in the cortex encodes migraine…
and reduces sensitivity to cranial pain triggers in migraine mice. Recently, we found that …

… altered cortical physiology in a genetic mouse model of familial hemiplegic migraine type 2
(… We then investigated whether synaptic activity is altered in FHM2 mice. We first recorded …

… expression in the cortex and hippocampus in migraine mice, especially in the hippocampal
CA1 and DG regions, where there are numerous pyramidal cells and synaptic connections. It …

… synaptic activity by breakdown of ATP could decrease glutamate release from thalamocortical
nerve endings and suppress post-synaptic … occipital cortex epidurally (0.7–1 mM) in 5 mice …

… at cortical synapses during neuronal activity and sensory stimulation. Here we review the
migraine-… glutamate transport dysfunction in FHM2 mice and their underlying mechanisms, in …

… that awake mice carrying a familial hemiplegic migraine type … of inefficient clearance following
synaptic release. Importantly, … by cortical astrocytes in familial hemiplegic migraine type 2. …

… cortical of C57BL/6 male mouse, compared with a single dose of OT administration [16]. A
recently published review concludes that repeated OT administration closely resembles long-…