Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance
C Lodillinsky, L Fuhrmann, M Irondelle, O Pylypenko… - Oncogene, 2021 - nature.com
… components of breast tumor cells relative … MT1-MMP levels in the invasive components of
breast tumors, particularly in aggressive histological grade III and triple-negative breast cancers…
breast tumors, particularly in aggressive histological grade III and triple-negative breast cancers…
SNX27–retromer assembly recycles MT1-MMP to invadopodia and promotes breast cancer metastasis
… in the metastatic breast cancer cell line MDA-MB-231, retromer regulates the matrix
invasion activity by recycling matrix metalloprotease, MT1-MMP. We further found that MT2-MMP, …
invasion activity by recycling matrix metalloprotease, MT1-MMP. We further found that MT2-MMP, …
[HTML][HTML] Target engagement of an anti-MT1-MMP antibody for triple-negative breast cancer PET imaging and beta therapy
N Magro, M Oteo, E Romero… - Nuclear Medicine and …, 2024 - Elsevier
… cancer cells for the specific delivery of ionizing radiation. Given that MT1-MMP is overexpressed
in MDA-MB-231 cells … mediated by MT1-MMP binding, TRT against MT1-MMP may have …
in MDA-MB-231 cells … mediated by MT1-MMP binding, TRT against MT1-MMP may have …
MT1-MMP as a key regulator of metastasis
N Tanaka, T Sakamoto - Cells, 2023 - mdpi.com
… The promoter of MT1-MMP in breast cancer cells MCF-7, which lack MT1-… In certain breast
cancer cells, SNX27 is associated with the proper trafficking of MT1-MMP to the cell surface …
cancer cells, SNX27 is associated with the proper trafficking of MT1-MMP to the cell surface …
Interference-free SERS nanoprobes for labeling and imaging of MT1-MMP in breast cancer cells
… matrix metalloproteinase (MT1-MMP) in cancer cells is critical for understanding the development,
invasion and metastasis of cancers… expression of MT1-MMP in breast cancer cells has …
invasion and metastasis of cancers… expression of MT1-MMP in breast cancer cells has …
Cancer cell extravasation requires iplectin-mediated delivery of MT1-MMP at invadopodia
OR Grafinger, JJ Hayward, Y Meng… - … Journal of Cancer, 2024 - nature.com
… Mass spectrometry and immunoprecipitation were used to identify interactors of MT1-MMP
in metastatic breast cancer cells. After identification, siRNA and small molecule inhibitors …
in metastatic breast cancer cells. After identification, siRNA and small molecule inhibitors …
Novel roles of MT1-MMP and MMP-2: beyond the extracellular milieu
DV Maybee, NL Ink, MAM Ali - International journal of molecular sciences, 2022 - mdpi.com
… Likewise, TIMP-1 was found to translocate to the nucleus of human MCF-7 breast
carcinoma cells after binding to the cell surface [103]. This response of TIMP-1 immediately …
carcinoma cells after binding to the cell surface [103]. This response of TIMP-1 immediately …
Regulation of MT1-MMP activity through its association with ERMs
H Suárez, S López-Martín, V Toribio, M Zamai… - Cells, 2020 - mdpi.com
… To have a functional readout of the relevance of MT1-MMP interaction with ERMs, we used
… , in a breast carcinoma cell model that has no endogenous expression of MT1-MMP. In these …
… , in a breast carcinoma cell model that has no endogenous expression of MT1-MMP. In these …
MT1-MMP enhances cell survival and proliferation via roles unrelated to metabolic transcript levels in MCF7 breast cancer cells
RA Wise - 2022 - search.proquest.com
… breast cancer cells that overexpress high levels of MT1MMP (C1), slightly overexpress low
levels of MT1-MMP (C3) or express a mutated form of MT1-MMP … In this study, these cells …
levels of MT1-MMP (C3) or express a mutated form of MT1-MMP … In this study, these cells …
[HTML][HTML] Exploring the integrated role of AKT2, CD44v6, and MT1-MMP as predictors of axillary lymph node metastasis in invasive breast carcinoma of no special type
P Rustamadji, E Wiyarta… - Iranian Journal of …, 2022 - ncbi.nlm.nih.gov
… This finding is consistent with the molecular mechanism of CD44v6, which has been shown
to improve the capacity of invasive breast cancer cells to proliferate, migrate, invade, and …
to improve the capacity of invasive breast cancer cells to proliferate, migrate, invade, and …
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