… 2A), we analyzed the mucus detaching properties of new generation ENaC inhibitors in
mouse ileum. Compound A was previously evaluated for its ability to inhibit ENaC (Åstrand et al., …

… In cystic fibrosis (CF) pigs, loss of cystic fibrosis transmembrane conductance regulator (CFTR)
anion channels produced submucosal gland mucus that … these variables alter mucus, we …

… Because SMG mucus in naïve porcine models … mucus layer (12–15), we investigated whether
strand formation was unique to SMG mucus, ie, not a feature of superficial epithelial mucus…

… Question Cystic fibrosis (CF) is characterised by the accumulation of viscous adherent
mucus in the lungs. While several hypotheses invoke a direct relationship with cystic fibrosis …

… In CF, dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) … of
mucus, as well as bacterial killing. As a result of altered mucus properties, mucus detachment …

… MCT is defective in cystic fibrosis (CF), a life-threatening genetic disease caused by
mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) …

… mucus in muco-obstructive lung diseases, eg, cystic fibrosis (CF), chronic obstructive pulmonary
… compression of the mucus layer onto the airway surface with the formation of adherent …

… Cystic fibrosis (CF), an autosomal genetic disorder caused by the dysfunction of the cystic
fibrosis … failed mucociliary clearance due to abnormal mucus biophysical properties. In recent …

The highly complex and variable genotype–phenotype relationships observed in cystic fibrosis
(CF) have been an area of growing interest since the discovery of the CF transmembrane …

… and discuss the properties, function, and clinical translational relevance of pulmonary mucus
and assess it as a potential treatment target in pneumonia and chronic pulmonary disease. …