Improved prediction of protein-protein interactions using AlphaFold2

P Bryant, G Pozzati, A Elofsson - Nature communications, 2022 - nature.com
… of proteinprotein interactions can be divided into two categories, the identification of what
proteins interact and the identificationmultiple models of the same proteinprotein interaction

A deep-learning framework for multi-level peptide–protein interaction prediction

Y Lei, S Li, Z Liu, F Wan, T Tian, S Li, D Zhao… - Nature …, 2021 - nature.com
… in peptide-protein interaction prediction and identification of … are two mainstream approaches
for protein–ligand interaction … sequence information to model the interactions. For example, …

Reliable identification of protein-protein interactions by crosslinking mass spectrometry

S Lenz, LR Sinn, FJ O'Reilly, L Fischer… - Nature …, 2021 - nature.com
Protein-protein interactions govern most cellular pathways and processes, and multiple
Assessing the error of interaction networks has been a challenge. Crosslinking mass …

De novo design of protein interactions with learned surface fingerprints

P Gainza, S Wehrle, A Van Hall-Beauvais, A Marchand… - Nature, 2023 - nature.com
… of molecular recognition, we introduce a protein design … fully buried patches of the interface
to drive protein interactions. … side of the interaction could consist of one or multiple chains (for …

[HTML][HTML] Biomechanical characterization of SARS-CoV-2 spike RBD and human ACE2 protein-protein interaction

W Cao, C Dong, S Kim, D Hou, W Tai, L Du, W Im… - Biophysical journal, 2021 - cell.com
… The RBD-ACE2 interaction is a crucial step to mediate the host cell … interaction with the
SARS-CoV-2 S protein has a higher affinity than its binding with the structurally identical S protein

Recent advances in the development of proteinprotein interactions modulators: mechanisms and clinical trials

H Lu, Q Zhou, J He, Z Jiang, C Peng, R Tong… - Signal transduction and …, 2020 - nature.com
… However, HTS has been proved to be useful in the identification of molecules at the initial …
the hydrophobic interaction is the major interaction force between the two proteins. The key …

Fast end-to-end learning on protein surfaces

F Sverrisson, J Feydy, BE Correia… - … Pattern Recognition, 2021 - openaccess.thecvf.com
… approach, we test it on two tasks in the field of protein structural bioinformatics: the identification
of interaction sites and the prediction of protein-protein interactions. On both tasks, we …

Cross-linking mass spectrometry for investigating protein conformations and proteinprotein interactions─ a method for all seasons

L Piersimoni, PL Kastritis, C Arlt, A Sinz - Chemical Reviews, 2021 - ACS Publications
… linker, between two functional groups in a protein or a protein complex. The … interactions,
as well as analysis of structural dynamics of proteins in their native state, including identification

Graph-based prediction of protein-protein interactions with attributed signed graph embedding

F Yang, K Fan, D Song, H Lin - BMC bioinformatics, 2020 - Springer
… ) [4] and mass spectrometric protein complex identification (MS-PCI) [5], … As the whole
interaction network is regarded as an … there exists an interaction between the two proteins, in our S-…

Lipid–protein and proteinprotein interactions in the pulmonary surfactant system and their role in lung homeostasis

O Cañadas, B Olmeda, A Alonso… - International journal of …, 2020 - mdpi.com
interactions within lung surfactant and how multiple lipid–protein and proteinprotein
interactions … cellular inflammatory response via interaction with pattern-recognition receptors and …