Small-cell lung cancer

CM Rudin, E Brambilla, C Faivre-Finn… - Nature Reviews Disease …, 2021 - nature.com
Aspects of this heterogeneity have been implicated in tumour evolution, metastasis and
acquired therapeutic resistance. Although clinical progress in SCLC treatment has been …

Anti-cancer effect of boron derivatives on small-cell lung cancer

E Cebeci, B Yüksel, F Şahin - Journal of Trace Elements in Medicine and …, 2022 - Elsevier
… derivatives to the anti-cancer repertoire following the entry of … administration, and some
side effects such as peripheral … side effects and improved drug delivery capacity for cancer

18β-Glycyrrhetinic acid has anti-cancer effects via inducing apoptosis and G2/M cell cycle arrest, and inhibiting migration of A549 lung cancer cells

YH Luo, C Wang, WT Xu, Y Zhang, T Zhang… - OncoTargets and …, 2021 - Taylor & Francis
… -Gly had significant cytotoxic effects and no apparent side effects. 18β-Gly induced
mitochondria-dependent apoptosis of A549 lung cancer cells. In addition, after treatment with 18β-Gly…

[HTML][HTML] BMI1-mediated pemetrexed resistance in non-small cell lung cancer cells is associated with increased SP1 activation and cancer stemness

HT Shen, PJ Chien, SH Chen, GT Sheu, MS Jan… - Cancers, 2020 - mdpi.com
… in tumor cells and elevate the sensitivity of tumor cells to chemotherapy and radiotherapy for
tongue and breast cancer [… fewer side effects, make it a widely acceptable drug among lung

… inhibition of c-MET by podophyllotoxin promotes caspase-dependent apoptosis and suppresses cell growth in gefitinib-resistant non-small cell lung cancer cells

HN Oh, AW Kwak, MH Lee, E Kim, G Yoon, SS Cho… - Phytomedicine, 2021 - Elsevier
… The toxicity and side effects of anti-cancer drugs are constantly raised issues and hinder
the rapid development of new drugs. PPT derivatives of 1 mg/kg significantly inhibited …

Curcumin induces apoptosis in lung cancer cells by 14-3-3 protein-mediated activation of Bad

H Endo, I Inoue, K Masunaka… - Bioscience …, 2020 - academic.oup.com
… protects against cell death and increases the survival of cancer cells, we examined the
effects of … The expression levels of 14-3-3 proteins in A549 cells after treatment with various …

[HTML][HTML] Update 2020: management of non-small cell lung cancer

M Alexander, SY Kim, H Cheng - Lung, 2020 - Springer
… ≥ 50% or tumor infiltrating immune cells ≥ 10%, compared … with PD-L1 tumor cells ≥ 5%
or tumor infiltrating immune cells ≥ 5% [… Grade 3 or 4 treatment-related adverse effects were …

[HTML][HTML] Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo

J Fan, D Ren, J Wang, X Liu, H Zhang, M Wu… - Cell death & …, 2020 - nature.com
… The negative regulation of mTOR by AMPK is what links cellular energy and mTORC1
regulation 21 . ULK, a serine/threonine kinase, may function as a bridge between energy sensors (…

Immunotherapy for advanced non–small cell lung cancer: a decade of progress

MD Shields, JA Marin-Acevedo… - American Society of …, 2021 - ascopubs.org
… , with fewer side effects compared with classic chemotherapeutic agents. Multiple treatment
options are now available for patients with advanced non–small cell lung cancer, ranging …

[HTML][HTML] Immune checkpoint inhibitors for lung cancer treatment: a review

K Onoi, Y Chihara, J Uchino, T Shimamoto… - Journal of clinical …, 2020 - mdpi.com
… this article, the side effects of immune … side effects due to excessive autoimmune reactions,
which are relatively infrequent and if present, are usually mild, allowing continued treatment