Structural perspectives on the mechanism of soluble guanylate cyclase activation
EC Wittenborn, MA Marletta - International journal of molecular sciences, 2021 - mdpi.com
… H-NOXs are found as standalone proteins that interact with cognate signaling partners,
usually a histidine kinase or a diguanylate cyclase [40,41]. In contrast, obligate anaerobes …
usually a histidine kinase or a diguanylate cyclase [40,41]. In contrast, obligate anaerobes …
Current modulation of guanylate cyclase pathway activity—mechanism and clinical implications
G Grześk, A Nowaczyk - Molecules, 2021 - mdpi.com
For years, guanylate cyclase seemed to be homogenic and tissue nonspecific enzyme; … of
soluble guanylate cyclase. Treatment based on the modulation of guanylate cyclase function is …
soluble guanylate cyclase. Treatment based on the modulation of guanylate cyclase function is …
Guanylin Peptides Signaling: Insights into guanylate cyclase C dependent and Independent signaling pathways
I Strinic, N Habek, A Dugandžic - Journal of cellular signaling, 2021 - scientificarchives.com
… NPs activate membrane guanylate cyclases (GC), also called particulate GCs, and lead to
the production of their second messenger cyclic guanosine monophosphate (cGMP), which …
the production of their second messenger cyclic guanosine monophosphate (cGMP), which …
Activation mechanism of human soluble guanylate cyclase by stimulators and activators
… of NO signaling can lead to a spectrum of diseases 1,2,3,4 . NO signaling is initiated by the
… The cell lines were routinely checked to be negative for mycoplasma contamination but …
… The cell lines were routinely checked to be negative for mycoplasma contamination but …
Receptor guanylyl cyclase C and cyclic GMP in health and disease: perspectives and therapeutic opportunities
H Prasad, JKK Mathew… - Frontiers in Endocrinology, 2022 - frontiersin.org
… studies of the related soluble guanylate cyclase (sGC) protein, … region, re-arrange the two
cyclase domains into an active … expression is negatively regulated by Wnt signaling, they are …
cyclase domains into an active … expression is negatively regulated by Wnt signaling, they are …
A signaling factor linked to Toxoplasma gondii guanylate cyclase complex controls invasion and egress during acute and chronic infection
S Ye, M Lunghi, D Soldati-Favre - MBio, 2022 - Am Soc Microbiol
… Here, we characterized a novel component of the GC complex recently termed signaling …
by a guanylate cyclase complex conserved across the Apicomplexa. A signaling linked factor is …
by a guanylate cyclase complex conserved across the Apicomplexa. A signaling linked factor is …
Mutations in the vicinity of the IRAK3 guanylate cyclase center impact its subcellular localization and ability to modulate inflammatory signaling in immortalized cell …
… as a negative regulator of TLR signaling, although the molecular mechanism involved in
IRAK3-dependent modulation of NFκB activity is poorly defined. IRAK3 prevents dissociation of …
IRAK3-dependent modulation of NFκB activity is poorly defined. IRAK3 prevents dissociation of …
PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle
S Hildebrand, M Ibrahim, A Schlitzer… - Communications …, 2022 - nature.com
… signaling, we also performed correlation analysis for PREX1 in the same samples. We
observed significant negative … Furthermore, we found negative correlation between PREX1 and …
observed significant negative … Furthermore, we found negative correlation between PREX1 and …
The mitochondrial NO‐synthase/guanylate cyclase/protein kinase G signaling system underpins the dual effects of nitric oxide on mitochondrial respiration and …
VV Dynnik, EV Grishina, NI Fedotcheva - The FEBS Journal, 2020 - Wiley Online Library
… mtNOS/guanylate cyclase/protein kinase G signaling system (… of the enzymes of this signaling
system to evaluate its role in … inhibitors of NO synthase, guanylate cyclase, and kinase G, …
system to evaluate its role in … inhibitors of NO synthase, guanylate cyclase, and kinase G, …
Allosteric Communication of the Dimerization and the Catalytic Domain in Photoreceptor Guanylate Cyclase
… converting the absorbance of photons to electrical signals. Visual information is further
transmitted … (3) GUCY2D is the gene that encodes for photoreceptor guanylate cyclase GC-E (also …
transmitted … (3) GUCY2D is the gene that encodes for photoreceptor guanylate cyclase GC-E (also …
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