Protocadherin 20 maintains intestinal barrier function to protect against Crohn's disease by targeting ATF6

S Huang, Z Xie, J Han, H Wang, G Yang, M Li, G Zhou… - Genome Biology, 2023 - Springer
… In this study, we describe a critical role for PCDH20 in maintaining intestinal homeostasis.
Intestinal-… However, we detected only the T310 and S288 phosphosites of p120-catenin as no …

Ruscogenin attenuates sepsis-induced acute lung injury and pulmonary endothelial barrier dysfunction via TLR4/Src/p120-catenin/VE-cadherin signalling pathway

Y Wang, L Xue, Y Wu, J Zhang, Y Dai… - Journal of Pharmacy …, 2021 - academic.oup.com
… of VE-cadherin and maintains endothelial barrier function. [41] Decreased expression of
pulmonary VE-cadherin and p120-catenin were observed in animal models of sepsis-induced …

EpCAM is essential for maintenance of the small intestinal epithelium architecture via regulation of the expression and localization of proteins that compose adherens …

G Chen, Y Yang, W Liu, L Huang… - International …, 2021 - spandidos-publications.com
intestines, and is essential for maintaining the homeostasis of the intestinal epithelium…
EpCAM protein is localized at tight junctions and the basolateral membrane of the intestinal

Adherens junction proteins on the move—From the membrane to the nucleus in intestinal diseases

LR Lessey, SC Robinson, R Chaudhary… - Frontiers in Cell and …, 2022 - frontiersin.org
… cofactors (α, β, γ, and p120-catenin). One organ where … essential for normal intestinal
homeostasis, studies from our lab and others have explored Kaiso’s role in the mammalian intestine

Trans-compartmental regulation of tight junction barrier function

AN Naser, Q Lu, YH Chen - Tissue Barriers, 2023 - Taylor & Francis
… , demonstrating disruption of the intestinal barrier function. This study highlights the essential
role of p120 ctn in maintaining TJ barrier function and intestinal homeostasis. Citation34 …

p120-Catenin suppresses NLRP3 inflammasome activation in macrophages

P Kanmani, HEH Elkafas, M Ghazal… - … of Physiology-Lung …, 2023 - journals.physiology.org
… Here we investigated the role of p120-catenin expression in … Depletion of p120-catenin
in murine bone marrow-derived … Coimmunoprecipitation analysis showed that p120-catenin

ROCK1 inhibitor stabilizes E-cadherin and improves barrier function in experimental necrotizing enterocolitis

C Buonpane, C Yuan, D Wood… - … -Gastrointestinal …, 2020 - journals.physiology.org
maintaining normal barrier homeostasis. Rho-associated protein kinase-1 (ROCK1) is a kinase
that regulates the E-cadherin complex, and p120-catenin is … gastrointestinal homeostasis. …

[PDF][PDF] Investigating Non-tight Junction Functions of Claudin-7: Regulating Large Intestine Stem Cell Functions and Niche Maintenance, and Junctional Protein …

A Naser - 2022 - core.ac.uk
… is highly expressed in the intestine at both the apical … is essential for barrier function and
intestinal homeostasis as deletion of claudin-7 in mouse models induces an inflammatory bowel

Monoubiquitination of p120-catenin is essential for TGFβ-induced epithelial-mesenchymal transition and tumor metastasis

Q Wu, G Li, C Wen, T Zeng, Y Fan, C Liu, GF Fu… - Science …, 2020 - science.org
… , we therefore used p120-catenin 1A and 3A to examine the interaction between p120-catenin
and Smurf1 by coimmunoprecipitation assay. We found that both p120-catenin 1A and 3A …

Impact of epithelial cell shedding on intestinal homeostasis

PA Ngo, MF Neurath, R López-Posadas - International Journal of …, 2022 - mdpi.com
… maintains barrier function. Disturbance in cell shedding can create transient gaps (leaky …
In fact, simultaneous loss of p120 catenin and Kras activation resulted in basal extrusion, …