… that genes at the crossroads between cancer and neurodegeneration may be … between
cancer suppression and age-promoting processes [114]. Indeed, further evidence regarding p53 …

… P53, a transcriptional factor, has shown multiple functions in the crossroads among cancer
and neurodegenerative disorders such as HD, PD, and AD. p53 demonstrates a central role …

… In addition, as people grow older, the risk of co-occurrence tumor and neurodegenerative
diseases increases significantly; whether and how p53 is involved in this process should be …

… to suffer from neurodegeneration that was … p53-defective cancer cell lines [172], highlighting
the need for further studies for clarification. While the diverse functional portfolio of p53 …

… of p53 depends on the levels of an N-terminally truncated p53 … neurodegeneration, not
completely excluding that this p53 … the formation of NFTs, neurodegeneration, and accelerated …

… We recently reported a modulatory effect of TAU on the tumor suppressor P53 and down-stream
function such as apoptosis and senescence [80]. All these data support a role of TAU …

… indicate that neurodegeneration and cancers represent two … The most common tumor
suppressor protein TP53 (p53) has … ), lie at the crossroads of molecular pathways involved in …

… form of brain tumor [15]. Li-Fraumeni syndrome patients with germline p53 mutations
develop brain tumors [16]. As the importance of p53 in CNS development and cancer has been …

… In the following paragraphs we will briefly discuss the evidence linking these gene
products to cancer, extending the discussion to P53 and PIN1. The serine/threonine glycogen …

… In conclusion, p53 is located at the intersection between mtROS and the necroptosis …
cancer cells, but detrimental under conditions of inflammation, ischemia, neurodegeneration or …