… Host cells recognize blockade of caspase‐8‐mediated apoptosis by bacterial pathogens,
and trigger necroptosis as a backup defence strategy. Shigella flexneri counteracts this by type…

… as a safeguard to pathogenic inhibition of caspase-8. Overall, increasing amounts of
evidence point to caspase-8 as a molecule able to direct cells toward different types of death. …

… pathogenic Yersinia, activates RIPK1 and caspase-8–dependent cell death that promotes
antibacterial defense. While recent studies demonstrate that caspase-8 … pathogen blockade of …

… Cell death plays an important role during pathogen … and caspase-8 enzymatic activity,
which trigger the mitochondrial apoptotic effectors, BAX and BAK. The pro-apoptotic caspase-8 …

… Mice with T reg -specific loss of Caspase-8 that survived the exaggerated inflammatory …
pathogens that are not normally cleared in wild-type (WT) mice. The rapid attrition of caspase-8–…

… , which serves as the first line of defense against pathogens. … a caspase-8 mutant mouse
with a deficiency in caspase-8 … , caspase-3 was activated downstream of caspase-8 to …

… )—failed to induce cell death and cleavage of caspases 8 and 3 as seen with murine TNF (SI
… anthracis host–pathogen interactions and identifies TNF-induced caspase-8 activation and …

… promotes the clearance of intracellular pathogens by exposing them to recruited … pathogens
such as Yersinia. Another open question is the molecular requirements for caspase-8–…

… Blockade of TAK1 kinase activity with the specific inhibitor 5z-7-oxozeaenol (5z7) mimics
the effect of YopJ and pathogenic Yersinia infection to cause RIPK1–caspase-8–dependent …

… RIPK3 can also complex with RIPK1, FADD, and caspase-8, which induces caspase-8 …
pathogen sensor for the induction and processing of IL-1beta via a noncanonical caspase-8 …