N-acetylserotonin protects PC12 cells from hydrogen peroxide induced damage through ROS mediated PI3K/AKT pathway

J Kang, Y Wang, X Guo, X He, W Liu, H Chen, Z Wang… - Cell Cycle, 2022 - Taylor & Francis
… stimulated PC12 cells. In conclusion, NAS protected PC12 cells from apoptosis and oxidative
stress … by H 2 O 2 by inhibiting ROS activity and activating the PI3K/AKT signaling pathway. …

PI3K/Akt signaling pathway ameliorates oxidative stress-induced apoptosis upon manganese exposure in PC12 cells

Y Tan, H Cheng, C Su, P Chen, X Yang - Biological Trace Element …, 2022 - Springer
… pretreatment also increased cell apoptosis given the upregulated Bax and Caspase-3
mRNAs and decreased Bcl-2 mRNA. In summary, the PI3K/Akt signaling pathway can be …

… Possesses Protective Potentials on H2O2‐Stimulated PC12 Cells by Suppression of Oxidative Stress‐Induced Apoptosis through Regulation of PI3K/Akt Signal Pathway

RL Li, Q Zhang, J Liu, J Sun, LY He… - … and Cellular …, 2020 - Wiley Online Library
Cell Viability after the Inhibition of Signaling Pathway To further examine the role of the
PI3K/Akt signaling pathway in HAS protecting PC12 cells … of the PI3K/Akt signaling pathway by …

[HTML][HTML] Hederagenin protects PC12 cells against corticosterone-induced injury by the activation of the PI3K/AKT pathway

R Lin, L Liu, M Silva, J Fang, Z Zhou, H Wang… - Frontiers in …, 2021 - frontiersin.org
… Hederagenin stimulated the phosphorylation of AKT in PC12 cells. (A,B) PC12 cells were …
The expression of phosphorylated AKT, total AKT and GAPDH were detected by Western …

α‐Lipoic acid alleviates ferroptosis in the MPP+‐induced PC12 cells via activating the PI3K/Akt/Nrf2 pathway

L Liu, S Yang, H Wang - Cell Biology International, 2021 - Wiley Online Library
… role of PI3K/Akt/Nrf2, we first treated PC12 cells with a PI3K inhibitor LY294002, an Akt inhibitor
… the levels of p-PI3K, p-AKT, and Nrf2 using Western blot analysis. Markedly inhibited p-…

Grape seed proanthocyanidins protect PC12 cells from hydrogen peroxide-induced damage via the PI3K/AKT signaling pathway

X He, X Guo, Z Ma, Y Li, J Kang, G Zhang, Y Gao… - Neuroscience …, 2021 - Elsevier
PC12 cells from oxidative damage induced by H 2 O 2 via the PI3K/AKT signaling pathway.
… effects of the PI3K/AKT signaling pathway on H 2 O 2 -treated PC12 cells, we added the …

Adipose mesenchymal stem cell‐derived exosomes enhance PC12 cell function through the activation of the PI3K/AKT pathway

Y Xie, Y Chen, Y Zhu, X Chen, T Lin… - Stem Cells …, 2021 - Wiley Online Library
… of PI3K/AKT in PC12 cells. (a) The expression levels of p-PI3K and p-AKT were analyzed in
PC12 cells with … (b) The ADSC-exo-induced levels of p-PI3K and p-AKT were interrupted by …

Hydroxytyrosol Alleviated Hypoxia‐Mediated PC12 Cell Damage through Activating PI3K/AKT/mTOR‐HIF‐1α Signaling

X Li, X Tian, T Liu, M Li, W Wang… - … Medicine and Cellular …, 2022 - Wiley Online Library
PI3K/AKT/mTOR-HIF-1α Signaling Pathway The result of hydroxytyrosol on hypoxia-induced
PC12 cell of PI3K/AKT/mTOR-HIF-1α signaling pathway … expressions of PI3K, p-AKT, and p-…

… oxygen and glucose deprivation/reperfusion-induced PC12 cell injury through inhibition of apoptosis and autophagy by activating the PI3K/AKT/mTOR pathway

J Meng, H Ma, Y Zhu, Q Zhao - European Journal of Pharmacology, 2021 - Elsevier
… /R-induced neuronal injury in PC12 cells. In this study, PC12 cells were subjected to OGD
… autophagy following OGD/R in PC12 cells. Results may provide pharmacological evidence …

The protection impact of tectoridin on PC12 cell preventing OGD/R-caused damage through PI3K/AKT signaling channel

M Chen, Y Lu, M Zhou, W Wang, M Zheng… - European Journal of …, 2023 - Elsevier
… The results unambiguously suggested that tectoridin reduced OGD/R-caused damage to
PC12 cells and might ensure neuroprotection by stimulating the PI3K/AKT signaling channel. …