The clinical aspect of NTRK-fusions in pediatric papillary thyroid cancer

JC Ricarte-Filho, S Halada, A O'Neill… - Cancer genetics, 2022 - Elsevier
… Although adult and pediatric papillary thyroid cancer (PTC) … In pediatric PTC, fusion
oncogenes involving chromosomal … cohort of NTRK-driven pediatric PTC cases with an updated …

Pediatric papillary thyroid carcinoma: outcomes after surgery without adjuvant radioactive iodine

LE Castellanos, ME Zafereo, EM Sturgis… - The Journal of …, 2024 - academic.oup.com
Pediatric papillary thyroid carcinoma (PTC) has doubled in incidence over the past 40
years and accounts for > 90% of thyroid cancer … metastatic disease, children with PTC have …

Diverse oncogenic fusions and distinct gene expression patterns define the genomic landscape of pediatric papillary thyroid carcinoma

A Stosic, F Fuligni, ND Anderson, S Davidson… - Cancer Research, 2021 - AACR
… and transcriptomes of pediatric and adult papillary thyroid carcinoma, with implications
for understanding the biology, diagnosis, and treatment of advanced disease in children. …

Molecular alterations in relation to histopathological characteristics in a large series of pediatric papillary thyroid carcinoma from a single institution

E Macerola, A Proietti, AM Poma, C Ugolini… - Cancers, 2021 - mdpi.com
Papillary thyroid carcinoma (PTC) in pediatric patients shows … In this large mono-institutional
cohort of pediatric PTCs, tumor … These results highlight the importance of testing pediatric

RET, NTRK, ALK, BRAF, and MET Fusions in a Large Cohort of Pediatric Papillary Thyroid Carcinomas

B Pekova, V Sykorova, S Dvorakova, E Vaclavikova… - Thyroid, 2020 - liebertpub.com
Pediatric papillary thyroid carcinoma (PTC) is a rare malignancy, but with increasing incidence.
Pediatric … Somatic point mutations in pediatric PTCs have been previously described and …

The Evolving Genomic Landscape of Pediatric Papillary Thyroid Cancer

JC Ricarte-Filho, AT Franco - Current Opinion in Endocrine and Metabolic …, 2023 - Elsevier
pediatric and adult tumors share many similar characteristics, but the prevalence of gene
fusions is much higher in pediatric … molecular features of pediatric papillary thyroid cancers and …

Pan-genomic characterization of high-risk pediatric papillary thyroid carcinoma

A Stenman, S Backman, K Johansson… - … -related cancer, 2021 - erc.bioscientifica.com
… as pediatric papillary thyroid carcinoma (pPTC) or pediatric follicular thyroid carcinoma, …
the parafollicular C-cells; namely pediatric medullary thyroid carcinoma. As in adult patients, the …

High incidence of distant metastasis is associated with histopathological subtype of pediatric papillary thyroid cancer-a retrospective analysis based on SEER

X Zeng, Z Wang, Z Gui, J Xiang, M Cao… - Frontiers in …, 2021 - frontiersin.org
… Compared to adult thyroid carcinoma, the prognosis of pediatric papillary thyroid cancer is
generally fair (3). The reported mortality rate of pediatric papillary thyroid cancer (PTC) is very …

DICER1 Mutations Occur in More Than One-Third of Follicular-Patterned Pediatric Papillary Thyroid Carcinomas and Correlate with a Low-Risk Disease and Female …

S Onder, O Mete, I Yilmaz, A Bayram, S Bagbudar… - Endocrine …, 2022 - Springer
… Some pediatric papillary thyroid carcinoma (PPTC) cohorts have suggested a preliminary
correlation with respect to DICER1 mutation status and histomorphology in both benign and …

Integrated DNA and RNA sequencing reveals targetable alterations in metastatic pediatric papillary thyroid carcinoma

SL Potter, J Reuther, R Chandramohan… - Pediatric Blood & …, 2021 - Wiley Online Library
Pediatric papillary thyroid carcinoma (PTC) is clinically and biologically distinct from adult …
of clinically annotated pediatric PTC cases enriched for high-risk tumors to identify genetic …