Perineuronal nets: subtle structures with large implications
H Carceller, Y Gramuntell, P Klimczak… - The …, 2023 - journals.sagepub.com
Perineuronal nets (PNNs) are specialized structures of the extracellular matrix that surround
the soma and proximal dendrites of certain neurons in the central nervous system, …
the soma and proximal dendrites of certain neurons in the central nervous system, …
Impact of perineuronal nets on electrophysiology of parvalbumin interneurons, principal neurons, and brain oscillations: a review
JC Wingert, BA Sorg - Frontiers in synaptic neuroscience, 2021 - frontiersin.org
… Perineuronal nets (PNNs) play such a critical role in PV interneuron function that recent cell-…
Finally, to bring together the broader implications of PNN removal on PV interneuron function…
Finally, to bring together the broader implications of PNN removal on PV interneuron function…
From molecules to behavior: Implications for perineuronal net remodeling in learning and memory
B Sanchez, P Kraszewski, S Lee… - Journal of …, 2023 - Wiley Online Library
… FIGURE 1 Overview of the structure and composition of perineuronal nets (PNNs). Many
different extracellular matrix components organize together to form the mesh- like structure of …
different extracellular matrix components organize together to form the mesh- like structure of …
Perineuronal Nets as Therapeutic Targets for the Treatment of Neuropsychiatric Disorders
… Perineuronal nets (PNNs) are condensed portions of the extracellular matrix (ECM) that
stabilize homeostatic synaptic plasticity, facilitate neuronal-glia communication, and provide a …
stabilize homeostatic synaptic plasticity, facilitate neuronal-glia communication, and provide a …
Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain
JD Crapser, EE Spangenberg, RA Barahona… - …, 2020 - thelancet.com
… We find that perineuronal nets are extensively lost in disease and identify the presence of
aggrecan, a critical net component, in human dense-… Implications of all the available evidence …
aggrecan, a critical net component, in human dense-… Implications of all the available evidence …
Neurocan contributes to perineuronal net development
S Schmidt, T Arendt, M Morawski, M Sonntag - Neuroscience, 2020 - Elsevier
… Perineuronal nets (PNs) are matrix molecule assemblies surrounding neuronal somata,
dendrites and axon initial segments in a lattice-like appearance. PN molecules are involved in …
dendrites and axon initial segments in a lattice-like appearance. PN molecules are involved in …
Perineuronal net density in schizophrenia: A systematic review of postmortem brain studies
JRF Lisboa, O Costa, GH Pakes, DAE Colodete… - Schizophrenia …, 2024 - Elsevier
… Some of these processes are proposed to depend on the development of perineuronal nets
(PNNs), a specialized extracellular matrix structure that surrounds preferentially parvalbumin…
(PNNs), a specialized extracellular matrix structure that surrounds preferentially parvalbumin…
Effects of early life stress on the developing basolateral amygdala-prefrontal cortex circuit: the emerging role of local inhibition and perineuronal nets
A Guadagno, C Belliveau, N Mechawar… - Frontiers in human …, 2021 - frontiersin.org
… We explore the effects of ELS on local inhibitory neurons and the formation of perineuronal
nets (PNNs) that terminate critical periods of plasticity and promote the formation of stable …
nets (PNNs) that terminate critical periods of plasticity and promote the formation of stable …
The mechanisms of perineuronal net abnormalities in contributing aging and neurological diseases
Y Dong, K Zhao, X Qin, G Du, L Gao - Ageing Research Reviews, 2023 - Elsevier
… The perineuronal net (PNN) is a highly latticed extracellular matrix in the central nervous
system, which is composed of hyaluronic acid, proteoglycan, hyaluronan and proteoglycan link …
system, which is composed of hyaluronic acid, proteoglycan, hyaluronan and proteoglycan link …
Perineuronal Nets: From Structure to Neurological Disorders
X Li, N Li, P Zhao, D Ren, B Luo… - Current Medicinal …, 2024 - ingentaconnect.com
… Notably, there are specialized dense matrix structures called perineuronal nets (PNN)
around neurons with holes at many synaptic contacts [1]. PNN was first described as “delicate …
around neurons with holes at many synaptic contacts [1]. PNN was first described as “delicate …
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