[HTML][HTML] Targeting PI3K/AKT signaling pathway in obesity

MS Savova, LV Mihaylova, D Tews, M Wabitsch… - Biomedicine & …, 2023 - Elsevier
PI3K/AKT signaling pathway that target obesity management is the main objective of this
review. The PI3K/AKT pathway … the PI3K/AKT signaling is provided. Moreover, druggability of …

Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression

C Xue, G Li, J Lu, L Li - Signal transduction and targeted therapy, 2021 - nature.com
… The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway … Emerging data suggest that
the circRNA/PI3K/AKT axis … circRNAs in the circRNA/PI3K/AKT axis is significantly associated …

The PI3K/AKT signaling pathway in cancer: Molecular mechanisms and possible therapeutic interventions

MR Khezri, R Jafari, K Yousefi, NM Zolbanin - Experimental and molecular …, 2022 - Elsevier
… of signaling molecules that regulate PI3K/AKT pathway with … relationship between the PI3K/AKT
signaling pathway and factors … regulating this signaling pathway have been summarized. …

Role of PI3K/Akt signaling pathway in cardiac fibrosis

W Qin, L Cao, IY Massey - Molecular and cellular biochemistry, 2021 - Springer
… -3 kinase (PI3K)/Akt signaling pathway in the cardiac fibrosis. First, we … PI3K/Akt in the
development of cardiac fibrosis via showing the main downstream targets of the PI3K/Akt pathway. …

PI3K/AKT/mTOR signaling pathway in breast cancer: from molecular landscape to clinical aspects

D Miricescu, A Totan, II Stanescu-Spinu… - International journal of …, 2020 - mdpi.com
… Currently, clinical studies evaluate inhibitors of the PI3K/AKT/mTOR … AKT signaling pathway,
the factors that activate this protein kinase B, PI3K/AKT-breast cancer mutations, PI3K/AKT/…

Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer

L Yu, J Wei, P Liu - Seminars in cancer biology, 2022 - Elsevier
… frequently dysregulated signaling pathways observed in … This is largely due to that PI3K/Akt/mTOR
signaling is … kinase components of the PI3K/Akt/mTOR signaling pathway have drawn …

PI3K/AKT signal pathway: a target of natural products in the prevention and treatment of Alzheimer's disease and Parkinson's disease

HZ Long, Y Cheng, ZW Zhou, HY Luo… - Frontiers in …, 2021 - frontiersin.org
… This article reviews the relationship between AKT signaling pathway and AD and PD, and
discusses the potential natural products based on the PI3K/AKT signaling pathway to treat two …

Targeting PI3K/AKT/mTOR signaling pathway in breast cancer

H Li, L Prever, E Hirsch, F Gulluni - Cancers, 2021 - mdpi.com
PI3K signaling pathway plays an essential role in many cellular processes and is frequently
… role of the PI3K signaling pathway and the most recently developed PI3K-targeting breast …

PI3K/Akt/mTOR signaling pathway in cancer stem cells

M Ebrahimi, E Nourbakhsh, AZ Hazara… - … -Research and Practice, 2022 - Elsevier
PI3K/Akt/mTOR pathway with inhibitors might be a promising strategy for targeted cancer
therapy. Although the pathway is … Here, we reviewed the PI3K/Akt/mTOR signaling pathway and …

Growth factors, PI3K/AKT/mTOR and MAPK signaling pathways in colorectal cancer pathogenesis: where are we now?

C Stefani, D Miricescu, II Stanescu-Spinu… - International journal of …, 2021 - mdpi.com
signaling pathwayPI3K/AKT signaling pathways are responsible for cancer cell survival
and invasion [148]. The Raf/mitogen-activated protein kinase (MEK)/ERK signaling pathways