… To cast light on sepsis pathogenesis and novel intervention therapeutic results, we systemically
… and focused on the molecular signaling pathways and intervention therapies in sepsis. …

… an overview of sepsis immune pathophysiology, to update the choice of therapeutic approaches
targeting different immunological mechanisms in the course of sepsis and septic shock, …

… , frequently addressing sepsis progression markers than the potential treatment strategies. …
new therapeutic targets enhancing the phagocytic process and clearance of pathogens. …

… Moreover, clinical reports have examined the efficacy of recombinant Flt3L (CDX-301),
demonstrating that rescuing DCs could be a promising therapeutic target for sepsis (41). …

… Cytokine storm generates during various systemic acute infections, including sepsis and …
lead to severe systemic inflammatory condition called sepsis in response to the generation of …

… sepsis patients. These biomarkers have been demonstrated to be involved in regulation of
sepsis pathophysiology. … -based biomarkers and their therapeutic potential in sepsis patients. …

… diagnostic potential of endothelial markers and endothelial pathways as therapeutic targets
… in vascular permeability in sepsis and point towards potential therapeutics to modulate this …

… Therefore, since MDSCs may be therapeutic target cells for sepsis-induced … with sepsis
is significantly increased, suggesting that CTLA-4 is a potential target for sepsis treatment [96]. …

… However, septic cardiomyopathy can also be induced by many other factors, making it …
contributing mechanisms in order to generate appropriate therapeutic targets (Figure 2). …

… Cardiovascular dysfunction plays a central role in the pathogenesis of sepsis with the major
role … of therapeutic targets that have a realistic probability of improving survival from sepsis. …