… Such non-conventional activities were predominantly reported in non-cancer cells although,
recently, such a dual function for pro-apoptotic proteins has also been reported in cancers …

… -resistant prostate cancer cells, … -8 pro-apoptotic function was inhibited via cFLIP binding.
Moreover, high caspase-8 expression was correlated with a worse prognosis in prostate cancer …

… At the post-translational level, BIM is regulated by phosphorylation, which have opposing
effects on pro-apoptotic BIM function depending on the kinases involved and the sites of …

… of anti-apoptotic, or downregulation of pro-apoptotic, BCL-2 proteins. A growing body of
evidence suggests this is the case in prostate cancer, an aspect of which is discussed in detail …

… of the pro-apoptotic BH3-only protein BAD at serine 136 [34]. In this way early genetic
events in prostate cancer may shift the balance in the BCL-2 family to favour cell survival. …

… Prostate cancer (PCa) is known as one of the most prevalent malignancies globally and is
not yet curable owing to its progressive nature. It has been well documented that Genetic and …

… might protect host cells from apoptosis, whereas E6 has pro-apoptotic attributes, and also
E7 might act as an antiapoptotic or pro-apoptotic factor, based on the cell sort. Overexpression …

… between pro-apoptotic and anti-apoptotic proteins, and their significance in cancer therapy.
… The function of these pro-apoptotic proteins is to promote apoptosis via the inhibition of anti-…

… -resistant prostate cancer (… prostate cancer cells. These findings indicate the clinical
relevance of topoisomerase II catalytic inhibitors in androgen receptor-negative prostate cancer. …

… Par-4 was originally identified in rat prostate cancer cells undergoing apoptosis 1 . The most
… This may explain why cancer cells are more prone to the pro-apoptotic effect of secreted Par…