… , androgen ablation therapy directed toward a reduction in serum androgens and the inhibition
of androgen receptor (… However, the patient’s response to androgen ablation therapy is …

… of advanced prostate cancer over the last two decades; however, the disease remains
invariably fatal. Androgens and the androgen receptor (AR) play a critical role in prostate …

… Understanding of the molecular mechanisms of prostate cancer has led to development of
therapeutic strategies targeting androgen receptor (AR). These androgen-receptor signaling …

… Suppression of androgen receptor (AR) signalling has been central to the treatment of
prostate cancer since the discovery of the sensitivity of this disease to testosterone in 1941 (ref. ). …

… Androgens signal via the androgen receptor, a ligand-… In this review we discuss the role of
the androgen receptor in PCa … to switch off the receptor or modify its function in cancer cells. …

… In prostate cancer, androgen steroid hormones bind to the androgen receptor (AR) and
thereby trigger a key lineage-specific, oncogenic transcriptional program [1]. For many decades, …

… Prostate secretory epithelial cells and neoplastic derivatives are dependent on the androgen
receptor … Currently, inhibition of AR signaling using androgen deprivation therapy (ADT), …

… Prostate cancer is a hormone-dependent malignancy, whose onset and … the androgen
receptor (AR) signaling pathway. Due to this critical role of AR signaling in driving prostate cancer, …

… Androgen receptor (AR) is a main driver of prostate cancer (PCa) growth and progression …
depending on the stage of cancer at diagnosis. Although androgen deprivation therapy (ADT) …

… cause of cancer death in American men. Prostate cancer depends on the androgen receptor
(AR), a transcriptional factor critical for prostate cancer growth and progression. Castration …