Controlling biofilm and virulence properties of Gram-positive bacteria by targeting wall teichoic acid and lipoteichoic acid

GJ Jeong, F Khan, N Tabassum, KJ Cho… - International Journal of …, 2023 - Elsevier
… Nevertheless, teichoic acid (TA) serves a similar role in surface attachment in Gram-… teichoic
acid (WTA), and when it is linked to the cell membrane, it is referred to as lipoteichoic acid (…

Structure of a proton-dependent lipid transporter involved in lipoteichoic acids biosynthesis

B Zhang, X Liu, E Lambert, G Mas, S Hiller… - Nature structural & …, 2020 - nature.com
Lipoteichoic acids (LTAs) are essential cell-wall components in Gram-positive bacteria,
including the human pathogen Staphylococcus aureus, contributing to cell adhesion, cell …

Cryo-EM analysis of S. aureus TarL, a polymerase in wall teichoic acid biogenesis central to virulence and antibiotic resistance

FKK Li, LJ Worrall, RT Gale, ED Brown… - Science …, 2024 - science.org
… , and its synthesis is catalyzed by a set of teichoic acid glycerol (Tag) enzymes. The addition
… of not only WTA biogenesis but also the biogenesis of other glycoconjugates that rely on the …

The length of lipoteichoic acid polymers controls Staphylococcus aureus cell size and envelope integrity

AR Hesser, LM Matano, CR Vickery… - Journal of …, 2020 - Am Soc Microbiol
… Here, we show that controlling the length of an essential cell envelope polymer, lipoteichoic
acid, is critical for controlling S. aureus cell size and cell envelope integrity. We also show …

The function of CozE proteins is linked to lipoteichoic acid biosynthesis in Staphylococcus aureus

MD Barbuti, E Lambert, IS Myrbråten, A Ducret… - Mbio, 2024 - Am Soc Microbiol
… In this work, we discover that a family of membrane proteins named CozE is involved in the
biosynthesis of lipoteichoic acids (LTAs) in S. aureus. CozE proteins have previously been …

[HTML][HTML] Crystallographic analysis of Staphylococcus aureus LcpA, the primary wall teichoic acid ligase

FKK Li, FI Rosell, RT Gale, JP Simorre… - Journal of Biological …, 2020 - ASBMB
… Their cell walls are composed of a thick layer of peptidoglycan (PG) modified by the attachment
of wall teichoic acid (WTA), an anionic glycopolymer that is linked to pathogenicity and …

Bifidobacteria cell wall-derived exo-polysaccharides, lipoteichoic acids, peptidoglycans, polar lipids and proteins–their chemical structure and biological attributes

M Pyclik, D Srutkova, M Schwarzer, S Gorska - International journal of …, 2020 - Elsevier
… , lipoteichoic acids, polar lipids, peptidoglycans and proteins. We discuss their involvement
in direct signaling to the host cells and their described immunomodulatory effects. …

Anti-biofilm mechanism of lipoteichoic acids from Lactobacilli and their therapeutic potential against periodontitis

이동욱 - 2023 - s-space.snu.ac.kr
… Since lipoteichoic acids (LTAs) are known to inhibit some oral bacterial … In addition,
Lactobacillus derivatives such as lipoteichoic acid (LTA), polysaccharides, biosurfactants, and …

Insights into the Roles of Lipoteichoic Acids and MprF in Bacillus subtilis

A Guyet, A Alofi, RA Daniel - Mbio, 2023 - Am Soc Microbiol
proteins (aPBPs), which function in peptidoglycan synthesis, is conditionally lethal. Here, we
show that this lethality is associated with an alteration of lipoteichoic acidslipoteichoic acids

lipoteichoic acids are essential for pneumococcal colonization and membrane integrity

M Brendel, TP Kohler, JV Neufend, A Puppe… - Journal of Innate …, 2024 - karger.com
… cell wall are teichoic acids (TAs), which offer a binding site for the family of choline-binding
proteins (… bacteria, pneumococcal wall teichoic acids (WTA) and lipoteichoic acids (LTA) have …