[HTML][HTML] Lessons in self-defence: inhibition of virus entry by intrinsic immunity

S Majdoul, AA Compton - Nature Reviews Immunology, 2022 - nature.com
… When the amphipathic helix is deleted from the context of the IFITM3 polypeptide, the protein
loses the capacity to increase membrane rigidity in living cells 58 . Furthermore, a peptide …

Cross-sectional study examining the status of intrinsic capacity decline in community-dwelling older adults in China: prevalence, associated factors and implications …

L Ma, JK Chhetri, L Zhang, F Sun, Y Li, Z Tang - BMJ open, 2021 - bmjopen.bmj.com
… This approach centres around the concept of raising intrinsic capacity (IC) and functional …
, IC comprises an individual’s physical and mental capacities at any given time.4 This novel …

[HTML][HTML] Integrated care for older people screening tool for measuring intrinsic capacity: preliminary findings from ICOPE pilot in China

L Ma, JK Chhetri, Y Zhang, P Liu, Y Chen, Y Li… - Frontiers in …, 2020 - frontiersin.org
… people with priority conditions associated with declines in intrinsic capacity (IC). We aimed
to determine the clinical utility of the WHO ICOPE screening tool in a Chinese population. …

[HTML][HTML] Intrinsically disordered proteins play diverse roles in cell signaling

SE Bondos, AK Dunker, VN Uversky - Cell Communication and Signaling, 2022 - Springer
… The goal of this collection is to highlight the many roles of intrinsic disorder in … intrinsically
disordered proteins, this review highlights the critical role of intrinsically disordered proteins for …

Mechanisms, regulation and functions of the unfolded protein response

C Hetz, K Zhang, RJ Kaufman - Nature reviews Molecular cell biology, 2020 - nature.com
… folding status to the nucleus and cytosol to adjust the protein folding capacity of the cell or,
in the event of chronic damage, induce apoptotic cell death. Recent advances in the …

ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response

S Nagarajan, SV Rao, J Sutton, D Cheeseman… - Nature …, 2020 - nature.com
… In support of the intrinsic regulation of proliferation by ARID1A, we assessed breast cancer
patients with ARID1A mutations compared to patients with WT ARID1A 27 , revealing a …

The concept of intrinsic versus extrinsic apoptosis

L Lossi - Biochemical Journal, 2022 - portlandpress.com
… Both the intrinsic and extrinsic pathways of apoptosis lead to the activation of a family of …
pathways of intrinsic and extrinsic apoptosis, discussing how they are activated in response to …

[HTML][HTML] Protein synthesis, degradation, and energy metabolism in T cell immunity

JM Marchingo, DA Cantrell - Cellular & molecular immunology, 2022 - nature.com
… production are intrinsically linked to proteome remodeling. In this review, we discuss how
protein synthesis … Hence, the capacity for protein synthesis is actively controlled during a T cell …

[HTML][HTML] The unfolded protein response mediator PERK governs myeloid cell-driven immunosuppression in tumors through inhibition of STING signaling

E Mohamed, RA Sierra, J Trillo-Tinoco, Y Cao… - Immunity, 2020 - cell.com
… Here, we investigated the role of the intrinsic activation of the … NRF2-driven antioxidant
capacity and impaired mitochondrial … A superior capacity to impair T cell proliferation and an …

Screening for intrinsic capacity and frailty in the primary care population with multimorbidity using the Integrated Care for Older People Screening Tool and two …

SZ Sim, X Ng, PSS Lee, HL Koh, SY Tan, TYG Ding… - 2024 - researchsquare.com
… and pre-frailty was 24% while those with reduced intrinsic capacity and frailty was 10%. We
… with reduced intrinsic capacity and pre-frailty and that of reduced intrinsic capacity and frailty …