Complex relationship between cardiac fibroblasts and cardiomyocytes in health and disease

C Hall, K Gehmlich, C Denning… - Journal of the American …, 2021 - Am Heart Assoc
… Our understanding of the mechanisms driving the cardiac fibroblast activation and … cardiac
myocyte function is accumulating. In this review, we focus on the importance of the fibroblast‐…

Resolvin D1 and E1 promote resolution of inflammation in rat cardiac fibroblast in vitro

A Salas-Hernández, C Espinoza-Pérez, R Vivar… - Molecular biology …, 2021 - Springer
Cardiac fibroblasts (CFs) have a key role in the inflammatory response after cardiac injury
and are necessary for wound healing. Resolvins are potent agonists that control the duration …

The diabetic cardiac fibroblast: mechanisms underlying phenotype and function

SP Levick, A Widiapradja - International Journal of Molecular Sciences, 2020 - mdpi.com
… also demonstrate myofibroblast pheno-conversion in response to HG [25,34], and isolated
adult rat cardiac fibroblasts underwent myofibroblast conversion (α-SMA) at a greater rate …

Regulators of cardiac fibroblast cell state

R Bretherton, D Bugg, E Olszewski, J Davis - Matrix Biology, 2020 - Elsevier
… Neonatal rat cardiac fibroblasts subject to cyclic compression assume a longer aspect
ratio with elevated expression of αSMA and an increase in transcription of matrix and matrix …

Exosomal lncRNA AK139128 derived from hypoxic cardiomyocytes promotes apoptosis and inhibits cell proliferation in cardiac fibroblasts

L Wang, J Zhang - International journal of nanomedicine, 2020 - Taylor & Francis
… Thus, we aimed to investigate the effect of hypoxia-induced exosomes on cardiac fibroblasts
(… exosomal AK139128 derived from hypoxic CMs could also exacerbate MI in the rat model. …

Cardiac fibroblasts mediate a sexually dimorphic fibrotic response to β‐adrenergic stimulation

AK Peter, CJ Walker, T Ceccato, CL Trexler… - Journal of the …, 2021 - Am Heart Assoc
… We found that male rats experienced increased cardiac hypertrophy, fibrosis, and death in
response to ISO treatment compared with female animals. In addition, when the response of …

MiR-21–3p triggers cardiac fibroblasts pyroptosis in diabetic cardiac fibrosis via inhibiting androgen receptor

P Shi, XD Zhao, KH Shi, XS Ding, H Tao - Experimental Cell Research, 2021 - Elsevier
… (e) Rat cardiac fibroblasts RNA was isolated, the miR-21–3p expression was assayed by …
focused on neonatal cardiac fibroblasts in this study, neonatal cardiac fibroblasts were used …

Defining the cardiac fibroblast secretome in a fibrotic microenvironment

TL Ceccato, RB Starbuck, JK Hall… - Journal of the …, 2020 - Am Heart Assoc
rats (200–250 g at arrival) were implanted randomly with either ascorbic acid (vehicle) or
isoproterenol pumps (4 mg/kg per day) for 3 days, rats were euthanized, and fibroblasts were …

Acellular bioscaffolds redirect cardiac fibroblasts and promote functional tissue repair in rodents and humans with myocardial injury

DA Svystonyuk, HEM Mewhort, AF Hassanabad… - Scientific Reports, 2020 - nature.com
… interacting with acellular scaffolds was evaluated in vivo using a rat model of human MI by
… Prior to scaffold delivery, we injected fluorescently labelled syngeneic rat cardiac fibroblasts

SGLT1 knockdown attenuates cardiac fibroblast activation in diabetic cardiac fibrosis

H Lin, L Guan, L Meng, H Uzui, H Guo - Frontiers in Pharmacology, 2021 - frontiersin.org
… an increase in SGLT1 expression in rat hearts triggered the development of cardiac fibrosis
through activation of CFs by upregulating the p38 MAPK and ERK1/2 signaling pathways. …