Complex relationship between cardiac fibroblasts and cardiomyocytes in health and disease
C Hall, K Gehmlich, C Denning… - Journal of the American …, 2021 - Am Heart Assoc
… Our understanding of the mechanisms driving the cardiac fibroblast activation and … cardiac
myocyte function is accumulating. In this review, we focus on the importance of the fibroblast‐…
myocyte function is accumulating. In this review, we focus on the importance of the fibroblast‐…
Resolvin D1 and E1 promote resolution of inflammation in rat cardiac fibroblast in vitro
A Salas-Hernández, C Espinoza-Pérez, R Vivar… - Molecular biology …, 2021 - Springer
… Cardiac fibroblasts (CFs) have a key role in the inflammatory response after cardiac injury
and are necessary for wound healing. Resolvins are potent agonists that control the duration …
and are necessary for wound healing. Resolvins are potent agonists that control the duration …
The diabetic cardiac fibroblast: mechanisms underlying phenotype and function
SP Levick, A Widiapradja - International Journal of Molecular Sciences, 2020 - mdpi.com
… also demonstrate myofibroblast pheno-conversion in response to HG [25,34], and isolated
adult rat cardiac fibroblasts underwent myofibroblast conversion (α-SMA) at a greater rate …
adult rat cardiac fibroblasts underwent myofibroblast conversion (α-SMA) at a greater rate …
Regulators of cardiac fibroblast cell state
R Bretherton, D Bugg, E Olszewski, J Davis - Matrix Biology, 2020 - Elsevier
… Neonatal rat cardiac fibroblasts subject to cyclic compression assume a longer aspect
ratio with elevated expression of αSMA and an increase in transcription of matrix and matrix …
ratio with elevated expression of αSMA and an increase in transcription of matrix and matrix …
Exosomal lncRNA AK139128 derived from hypoxic cardiomyocytes promotes apoptosis and inhibits cell proliferation in cardiac fibroblasts
L Wang, J Zhang - International journal of nanomedicine, 2020 - Taylor & Francis
… Thus, we aimed to investigate the effect of hypoxia-induced exosomes on cardiac fibroblasts
(… exosomal AK139128 derived from hypoxic CMs could also exacerbate MI in the rat model. …
(… exosomal AK139128 derived from hypoxic CMs could also exacerbate MI in the rat model. …
Cardiac fibroblasts mediate a sexually dimorphic fibrotic response to β‐adrenergic stimulation
… We found that male rats experienced increased cardiac hypertrophy, fibrosis, and death in
response to ISO treatment compared with female animals. In addition, when the response of …
response to ISO treatment compared with female animals. In addition, when the response of …
MiR-21–3p triggers cardiac fibroblasts pyroptosis in diabetic cardiac fibrosis via inhibiting androgen receptor
P Shi, XD Zhao, KH Shi, XS Ding, H Tao - Experimental Cell Research, 2021 - Elsevier
… (e) Rat cardiac fibroblasts RNA was isolated, the miR-21–3p expression was assayed by …
focused on neonatal cardiac fibroblasts in this study, neonatal cardiac fibroblasts were used …
focused on neonatal cardiac fibroblasts in this study, neonatal cardiac fibroblasts were used …
Defining the cardiac fibroblast secretome in a fibrotic microenvironment
TL Ceccato, RB Starbuck, JK Hall… - Journal of the …, 2020 - Am Heart Assoc
… rats (200–250 g at arrival) were implanted randomly with either ascorbic acid (vehicle) or
isoproterenol pumps (4 mg/kg per day) for 3 days, rats were euthanized, and fibroblasts were …
isoproterenol pumps (4 mg/kg per day) for 3 days, rats were euthanized, and fibroblasts were …
Acellular bioscaffolds redirect cardiac fibroblasts and promote functional tissue repair in rodents and humans with myocardial injury
DA Svystonyuk, HEM Mewhort, AF Hassanabad… - Scientific Reports, 2020 - nature.com
… interacting with acellular scaffolds was evaluated in vivo using a rat model of human MI by
… Prior to scaffold delivery, we injected fluorescently labelled syngeneic rat cardiac fibroblasts …
… Prior to scaffold delivery, we injected fluorescently labelled syngeneic rat cardiac fibroblasts …
SGLT1 knockdown attenuates cardiac fibroblast activation in diabetic cardiac fibrosis
H Lin, L Guan, L Meng, H Uzui, H Guo - Frontiers in Pharmacology, 2021 - frontiersin.org
… an increase in SGLT1 expression in rat hearts triggered the development of cardiac fibrosis
through activation of CFs by upregulating the p38 MAPK and ERK1/2 signaling pathways. …
through activation of CFs by upregulating the p38 MAPK and ERK1/2 signaling pathways. …
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