Neurokinin-1 Receptor Antagonism Reduces Nonallergic Ocular Redness in a Rabbit Model

L Liu, S Wang, T Blanco, H Ge, S Zhu, J Yin… - … Pharmacology and …, 2024 - liebertpub.com
… Effect of nonpeptide NK1 receptor antagonist L-703,606 on the edema formation in rats
at early stage after deep partial-thickness skin scalding. Asian Pac J Trop Med 2013;6(5):387–…

Hypothalamic neurokinin signalling and its application in reproductive medicine

K Skorupskaite, RA Anderson - Pharmacology & Therapeutics, 2022 - Elsevier
… Several antagonists to the neurokinin 3 receptor, for which neurokinin B is the endogenous
ligand, have been developed, and are entering clinical studies in human reproductive …

Neurokinin 3 receptor antagonism ameliorates key metabolic features in a hyperandrogenic PCOS mouse model

IE Sucquart, R Nagarkar, MC Edwards… - …, 2021 - academic.oup.com
… -/neurokinin B-/dynorphin (KNDy) system. This study aimed to investigate if targeted antagonism
of neurokinin B signaling through the neurokinin 3 receptor (… Similarly, rats prenatally …

[HTML][HTML] Neurokinin receptors and their implications in various autoimmune diseases

A Mishra, G Lal - Current Research in Immunology, 2021 - Elsevier
disease conditions such as inflammatory bowel disease, rheumatoid arthritis, multiple sclerosis,
psoriasis, and cancer. Neurokinin receptors … the various neurokinin receptor expression …

Effects of neurokinin 3 receptor antagonist fezolinetant on hot flash-like symptoms in ovariectomized rats

A Tahara, H Takamatsu, A Ohtake… - European Journal of …, 2021 - Elsevier
… , ovariectomized rats compared to control rats showed a significant increase in the number
of c-Fos-positive nuclei (a marker of neuronal activity) in the MnPO compared to control rats. …

Neuropeptide Y, calcitonin gene-related peptide, and neurokinin A in brain regions of HAB rats correlate with anxiety-like behaviours

L Carboni, A El Khoury, DI Beiderbeck… - European …, 2022 - Elsevier
… The high (HAB) and low (LAB) anxiety-related behaviour rats were selectively bred to … and
LAB rats. Increased anxiety and depression-like behaviours of male and female HAB rats in …

Neurokinin-1 receptor (NK-1R) antagonists: potential targets in the treatment of glioblastoma multiforme

AR Afshari, A Motamed-Sanaye, H Sabri… - Current medicinal …, 2021 - ingentaconnect.com
… After binding to the neurokinin-1 receptor (NK-1R), the SP controls cancer cell growth,
exerts antiapoptotic impacts, stimulates cell invasion/metastasis, and activates vascularization. …

Neurokinin 3 receptor antagonists–prime time?

JK Prague - Climacteric, 2021 - Taylor & Francis
… , and cardiovascular disease is increased in menopausal women but pre-clinical evidence
suggests that manipulation of neuronal signaling in the ventral tegmental area, which highly …

The neurokinin-1 receptor antagonist aprepitant: an intelligent bullet against cancer?

M Muñoz, R Coveñas - Cancers, 2020 - mdpi.com
… Currently, there are many data demonstrating the involvement of the substance P (SP)/neurokinin-1
receptor (NK-1R) system in cancer [2,3]; one of these targets could be the NK-1R, …

Neurokinin 1 and 2 receptors are involved in PGE2-and citric acid-induced cough and ventilatory responses

J Zhuang, X Gao, L Zhao, W Wei, F Xu - Respiratory Physiology & …, 2022 - Elsevier
receptors (a PGE 2 receptor) of vagal C-fibers respectively. Substance P (SP) and neurokinin
… and ventilation via preferentially activating neurokinin 1 and 2 receptors (NK 1 R and NK 2 …