Membrane fusion, a key step in the early stages of virus propagation, allows the release of
the viral genome in the host cell cytoplasm. The process is initiated by fusion peptides that …

Infection of human cells by the severe acute respiratory syndrome coronavirus 2 (SARS-
CoV2) relies on its binding to a specific receptor and subsequent fusion of the viral and host …

During infection the SARS-CoV-2 virus fuses its viral envelope with cellular membranes of
its human host. The viral spike (S) protein mediates both the initial contact with the host cell …

The membrane fusion mechanism of SARS-CoV-2 offers an attractive target for the
development of small molecule antiviral inhibitors. Fusion involves an initial binding of the …

Cell entry by SARS-CoV-2 is accomplished by the S2 subunit of the spike S protein on the
virion surface by capture of the host cell membrane and fusion with the viral envelope …

COVID-19, caused by SARS-CoV-2, which is a positive-sense, single-stranded RNA
enveloped virus, emerged in late 2019 and was declared a worldwide pandemic in early …

The emerging and re-emerging viral diseases are continuous threats to the wellbeing of
human life. Previous outbreaks of Severe Acute Respiratory Syndrome (SARS) and Middle …

An outbreak caused by 2019 novel coronavirus (2019-nCoV) was first identified in Wuhan
City, Hubei Province, China. The new virus was later named SARS-CoV-2. The virus has …

The SARS-CoV-2 virus has now become one of the greatest causes of infectious death and
morbidity since the 1918 flu pandemic. Substantial and unprecedented progress has been …

Fusion of lipid-enveloped viruses with the cellular plasma membrane or the endosome
membrane is mediated by viral envelope proteins that undergo large conformational …