Apolipoprotein E (ApoE) is of great interest due to its role as a cholesterol/lipid transporter in
the central nervous system (CNS) and as the most influential genetic risk factor for Alzheimer …

Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons
in the central nervous system. APOE-dependent alterations of the endocytic pathway can …

We applied a novel application of FLIM-FRET to in situ measurement and quantification of
protein interactions to explore isoform specific differences in Aβ-ApoE interaction and ApoE …

Despite intense interest, the molecular mechanisms underlying the association of apoE4
with Alzheimer disease are not clear. Because the function (or dysfunction) of a protein is …

Abstract Apolipoprotein E4 (apoE4) is a major risk factor for Alzheimer's disease (AD).
Several hypotheses have been proposed to explain the association of the APOE ε4 allele …

Exceptional advances have been made in understanding the genetics of how common
polymorphisms of the apolipoprotein E gene influence the risk and age of onset of Alzheimer …

Human apolipoprotein E (apoE) is a member of the family of soluble apolipoproteins.
Through its interaction with members of the low-density lipoprotein receptor family, apoE has …

Among the three human apolipoprotein E (apoE) isoforms, apoE4 increases the risk of
Alzheimer's disease (AD). While transporting cholesterol is a primary function, apoE also …

A key feature of Alzheimer's disease (AD) is deposition of extracellular amyloid plaque
comprised chiefly of the amyloid β (Aβ) peptide. Studies of Aβ have shown that it may be …

Alzheimer's disease (AD) is clinically characterized with progressive memory loss and
cognitive decline. Synaptic dysfunction is an early pathological feature that occurs prior to …