Nucleolin-Sle A glycoforms as E-selectin ligands and potentially targetable biomarkers at the cell surface of gastric cancer cells
Background: Gastric cancer (GC) is a major health burden worldwide, with half of patients
developing metastases within 5 years after treatment, urging novel biomarkers for diagnosis …
developing metastases within 5 years after treatment, urging novel biomarkers for diagnosis …
Glycan motif profiling reveals plasma sialyl-lewis x elevations in pancreatic cancers that are negative for sialyl-lewis A
The sialyl-Lewis A (sLeA) glycan forms the basis of the CA19–9 assay and is the current
best biomarker for pancreatic cancer, but because it is not elevated in∼ 25% of pancreatic …
best biomarker for pancreatic cancer, but because it is not elevated in∼ 25% of pancreatic …
[HTML][HTML] Integrative analysis of the expression of SIGLEC family members in lung adenocarcinoma via data mining
H Zhang, Y Xie, Z Hu, H Yu, X Xie, Y Ye, W Xu… - Frontiers in …, 2021 - frontiersin.org
Background: Sialic acid-binding immunoglobulin-type lectin (SIGLEC) family members are
involved in regulating immune-cell activation, proliferation, and apoptosis, and they play an …
involved in regulating immune-cell activation, proliferation, and apoptosis, and they play an …
[HTML][HTML] Carcinoembryonic antigen carrying SLeX as a new biomarker of more aggressive gastric carcinomas
C Gomes, A Almeida, A Barreira, J Calheiros… - Theranostics, 2019 - ncbi.nlm.nih.gov
Malignant transformation of gastric cells is accompanied by the deregulated expression of
glycosyltransferases leading to the biosynthesis of tumor-associated glycans such as the …
glycosyltransferases leading to the biosynthesis of tumor-associated glycans such as the …
Target score—a proteomics data selection tool applied to esophageal cancer identifies GLUT1-sialyl tn glycoforms as biomarkers of cancer aggressiveness
Esophageal cancer (EC) is a life-threatening disease, demanding the discovery of new
biomarkers and molecular targets for precision oncology. Aberrantly glycosylated proteins …
biomarkers and molecular targets for precision oncology. Aberrantly glycosylated proteins …
[HTML][HTML] Identification of LCA-binding glycans as a novel biomarker for esophageal cancer metastasis using a lectin array-based strategy
M Xia, J Shao, M Qiao, Z Luo, X Deng, Q Ke… - Journal of …, 2020 - ncbi.nlm.nih.gov
Esophageal cancer (EC) is a unique and heterogeneous disease diagnosed mostly at
advanced stages. Altered glycans presented on cell surfaces are involved in the occurrence …
advanced stages. Altered glycans presented on cell surfaces are involved in the occurrence …
Expression of ST3GAL4 Leads to SLex Expression and Induces c-Met Activation and an Invasive Phenotype in Gastric Carcinoma Cells
Sialyl-Lewis X (SLex) is a sialylated glycan antigen expressed on the cell surface during
malignant cell transformation and is associated with cancer progression and poor prognosis …
malignant cell transformation and is associated with cancer progression and poor prognosis …
sLea and sLex expression in colorectal cancer: implications for tumourigenesis and disease prognosis
S Villar Portela, C Vazquez Martin… - … histopathology, Vol. 26 …, 2011 - digitum.um.es
The glycoconjugates expressed by cancer cells frequently contain sialylated
oligosaccharide chains. Among these oligosaccharides the sialyl Lewis a (sLea) and sialyl …
oligosaccharide chains. Among these oligosaccharides the sialyl Lewis a (sLea) and sialyl …
[HTML][HTML] Esophageal, gastric and colorectal cancers: Looking beyond classical serological biomarkers towards glycoproteomics-assisted precision oncology
E Fernandes, J Sores, S Cotton, A Peixoto… - Theranostics, 2020 - ncbi.nlm.nih.gov
Abstract Esophageal (OC), gastric (GC) and colorectal (CRC) cancers are amongst the
digestive track tumors with higher incidence and mortality due to significant molecular …
digestive track tumors with higher incidence and mortality due to significant molecular …
Targeted proteo-glycomics analysis of Sialyl Lewis X antigen expressing glycoproteins secreted by human hepatoma cell line
K Higai, K Shibukawa, S Muto, K Matsumoto - Analytical sciences, 2003 - Springer
Abstract Sialyl Lewis X (SLEX) antigen, Neu5Ac α 2–3Gal β 1–4 (Fuc α 1–3) GlcNAc-R,
plays important roles in cell-to-cell interaction: for example, the E-and P-selectin-mediated …
plays important roles in cell-to-cell interaction: for example, the E-and P-selectin-mediated …