Osteoporosis is a complex multifactorial disorder of the skeleton. Genetic factors are
important in determining peak bone mass and structure, as well as the predisposition to …

Epigenetics describes mechanisms which control gene expression and cellular processes
without changing the DNA sequence. The main mechanisms in epigenetics are DNA …

Osteoporosis is a complex multifactorial condition of the musculoskeletal system.
Osteoporosis and osteoporotic vertebral fracture (OVF) are associated with high medical …

Abstract Purpose of Review Runt-related transcription factors (RUNX) play critical roles in
skeletal development, metabolism, and diseases. In mammals, three RUNX members …

Bone is a specialized connective tissue with a calcified extracellular matrix in which cells are
embedded. Besides providing the internal support of the body and protection for vital …

Bone metabolism consists of a balance between bone formation and bone resorption, which
is mediated by osteoblast and osteoclast activity, respectively. In order to ensure bone …

Throughout life, bone is continuously remodelled to be able to fulfil its multiple functions. The
importance of strictly regulating the bone remodelling process, which is defined by the …

In recent years, many articles have been published describing the impact of physical activity
and diet on bone health. This review has aimed to figure out the possible epigenetic …

Osteoporosis is a metabolic disease characterized by decreased bone mineral density and
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …

Osteoporosis is characterized by reduced bone formation and accumulation of adipocytes in
the bone marrow compartment. The decrease in bone mass results from an imbalance …