Bone is a major organ in the skeletal system that supports and protects muscles and other
organs, facilitates movement and hematopoiesis, and forms a reservoir of minerals including …

Carbohydrates, fats, and proteins are the underlying energy sources for animals and are
catabolized through specific biochemical cascades involving numerous enzymes. The …

Osteoporosis is a prevalent osteodegenerative disease and silent killer linked to a decrease
in bone mass and decline of bone microarchitecture, due to impaired bone matrix …

Osteoporosis is a bone disorder with remarkable changes in bone biologic material and
consequent bone structural distraction, affecting millions of people around the world from …

Introduction: Osteoporosis is the commonest metabolic bone disease worldwide. The clinical
hallmark of osteoporosis is low trauma fracture, with the most devastating being hip fracture …

A decline in bone mass leading to an increased fracture risk is a common feature of age-
related bone changes. The mechanisms underlying bone senescence are very complex and …

Background The runt-related transcription factor 2 (Runx2) is a cell-fate-determining factor
that controls osteoblast differentiation and bone formation. It has been previously …

Stimulation of bone formation is a key therapeutic target in osteoporosis. Runx2 is a runt
domain transcription factor essential to osteoblast differentiation, bone remodeling, and …

Despite years of research investigating osteoblast differentiation, the mechanisms by which
transcription factors regulate osteoblast maturation, bone formation, and bone homeostasis …

Osteoporosis is a major public health concern affecting millions of people worldwide and
resulting in significant economic costs. The condition is characterized by changes in bone …