[PDF][PDF] Steroids hydroxylation catalyzed by the monooxygenase mutant 139-3 from Bacillus
X Liu, J Kongn - Steroids - academia.edu
The search of new substrates with pharmaceutical and industrial potential for biocatalysts
including cytochrome P450 enzymes is always challenging. Cytochrome P450 BM3 mutant …
including cytochrome P450 enzymes is always challenging. Cytochrome P450 BM3 mutant …
[HTML][HTML] Steroids hydroxylation catalyzed by the monooxygenase mutant 139-3 from Bacillus megaterium BM3
X Liu, J Kong - Acta pharmaceutica sinica B, 2017 - Elsevier
The search of new substrates with pharmaceutical and industrial potential for biocatalysts
including cytochrome P450 enzymes is always challenging. Cytochrome P450 BM3 mutant …
including cytochrome P450 enzymes is always challenging. Cytochrome P450 BM3 mutant …
Hydroxylation of steroids by a microbial substrate-promiscuous P450 cytochrome (CYP105D7): key arginine residues for rational design
B Ma, Q Wang, H Ikeda, C Zhang… - Applied and …, 2019 - Am Soc Microbiol
Our previous study showed that CYP105D7, a substrate-promiscuous P450, catalyzes the
hydroxylation of 1-deoxypentalenic acid, diclofenac, naringenin, and compactin. In this …
hydroxylation of 1-deoxypentalenic acid, diclofenac, naringenin, and compactin. In this …
Towards preparative scale steroid hydroxylation with cytochrome P450 monooxygenase CYP106A2
D Zehentgruber, F Hannemann, S Bleif… - …, 2010 - Wiley Online Library
Cytochrome P450 monooxygenases are of outstanding interest for the synthesis of
pharmaceuticals and fine chemicals, due to their ability to hydroxylate C H bonds mainly in …
pharmaceuticals and fine chemicals, due to their ability to hydroxylate C H bonds mainly in …
H2O2-Driven Hydroxylation of Steroids Catalyzed by Cytochrome P450 CYP105D18: Exploration of the Substrate Access Channel
BD Pardhe, KP Kwon, JK Park, JH Lee… - Applied and …, 2023 - Am Soc Microbiol
ABSTRACT CYP105D18 supports H2O2 as an oxygen surrogate for catalysis well and
shows high H2O2 resistance capacity. We report the hydroxylation of different steroids using …
shows high H2O2 resistance capacity. We report the hydroxylation of different steroids using …
[HTML][HTML] Exploring the potential of cytochrome P450 CYP109B1 catalyzed regio—and stereoselective steroid hydroxylation
X Zhang, Y Hu, W Peng, C Gao, Q Xing… - Frontiers in …, 2021 - frontiersin.org
Cytochrome P450 enzyme CYP109B1 is a versatile biocatalyst exhibiting hydroxylation
activities toward various substrates. However, the regio-and stereoselective steroid …
activities toward various substrates. However, the regio-and stereoselective steroid …
Probing steroidal substrate specificity of cytochrome P450 BM3 variants
X Liu, ZB Wang, YN Wang, JQ Kong - Molecules, 2016 - mdpi.com
M01A82W, M11A82W and M01A82WS72I are three cytochrome P450 BM3 (CYP102A1)
variants. They can catalyze the hydroxylation of testosterone (TES) and norethisterone at …
variants. They can catalyze the hydroxylation of testosterone (TES) and norethisterone at …
Process development for the production of 15β-hydroxycyproterone acetate using Bacillus megaterium expressing CYP106A2 as whole-cell biocatalyst
FM Kiss, MT Lundemo, J Zapp, JM Woodley… - Microbial Cell …, 2015 - Springer
Abstract Background CYP106A2 from Bacillus megaterium ATCC 13368 was first identified
as a regio-and stereoselective 15β-hydroxylase of 3-oxo-∆ 4-steroids. Recently, it was …
as a regio-and stereoselective 15β-hydroxylase of 3-oxo-∆ 4-steroids. Recently, it was …
Rationally controlling selective steroid hydroxylation via scaffold sampling of a P450 family
X Zhang, P Shen, J Zhao, Y Chen, X Li, JW Huang… - Acs …, 2023 - ACS Publications
Many steroids are important pharmaceutically active compounds, while cytochrome P450
monooxygenases (CYPs) are attractive enzymes for applications in steroidal drug synthesis …
monooxygenases (CYPs) are attractive enzymes for applications in steroidal drug synthesis …
CYP260B1 acts as 9α-hydroxylase for 11-deoxycorticosterone
M Litzenburger, R Bernhardt - Steroids, 2017 - Elsevier
Steroids and their oxyfunctionalized counterparts are valuable compounds for the
pharmaceutical industry; however, the regio-and stereoselective introduction of oxygen is a …
pharmaceutical industry; however, the regio-and stereoselective introduction of oxygen is a …