Manganese superoxide dismutase is an essential component of the mitochondrial
antioxidant defense system of most eukaryotes. In the present study, we used a reverse …

We studied superoxide dismutases (SODs) in the encapsulated yeast Cryptococcus
neoformans (Cn) variety gattii to analyse the role of mitochondrial MnSOD (SOD2) in fungal …

Superoxide dismutase (SOD) is an enzyme that converts superoxide radicals into hydrogen
peroxide and molecular oxygen and has been shown to contribute to the virulence of many …

The pathogenic yeast Cryptococcus neoformans (Cn) var. gattii causes meningoencephalitis
in healthy individuals, unlike the better known Cn varieties grubii and neoformans, which are …

Cryptococcus neoformans is an environmental fungal pathogen that requires atmospheric
levels of oxygen for optimal growth. For the fungus to be able to establish an infection, it …

Mitochondria are essential organelles that act in pathways including ATP production, β-
oxidation, and clearance of reactive oxygen species. They occur as a complex reticular …

Cryptococcus neoformans is an opportunistic pathogen and the leading cause of fungal
meningitis. To survive within the host, this organism must be able to protect itself from …

Cryptococcus neoformans is a fungal pathogen most commonly causing meningitis in
immunocompromised patients. Current therapies are inadequate, and novel antifungal …

We identified a homologue of the alternative oxidase gene in a screen to identify genes that
are preferentially transcribed in response to a shift to 37° C in the human-pathogenic yeast …

The ability of the opportunistic fungal pathogen Cryptococcus neoformans to resist oxidative
stress is one of its most important virulence related traits. To cope with the deleterious effect …