The SARS-CoV fusion peptide forms an extended bipartite fusion platform that perturbs membrane order in a calcium-dependent manner
Coronaviruses (CoVs) are a major infectious disease threat and include the pathogenic
human pathogens of zoonotic origin: severe acute respiratory syndrome CoV (SARS-CoV) …
human pathogens of zoonotic origin: severe acute respiratory syndrome CoV (SARS-CoV) …
SARS-CoV-2 fusion peptide has a greater membrane perturbating effect than SARS-CoV with highly specific dependence on Ca2+
AL Lai, JH Freed - Journal of Molecular Biology, 2021 - Elsevier
Coronaviruses are a major infectious disease threat, and include the zoonotic-origin human
pathogens SARS-CoV-2, SARS-CoV, and MERS-CoV (SARS-2, SARS-1, and MERS). Entry …
pathogens SARS-CoV-2, SARS-CoV, and MERS-CoV (SARS-2, SARS-1, and MERS). Entry …
SARS-CoV fusion peptides induce membrane surface ordering and curvature
Viral membrane fusion is an orchestrated process triggered by membrane-anchored viral
fusion glycoproteins. The S2 subunit of the spike glycoprotein from severe acute respiratory …
fusion glycoproteins. The S2 subunit of the spike glycoprotein from severe acute respiratory …
Ca2+ Ions Promote Fusion of Middle East Respiratory Syndrome Coronavirus with Host Cells and Increase Infectivity
Fusion with, and subsequent entry into, the host cell is one of the critical steps in the life
cycle of enveloped viruses. For Middle East respiratory syndrome coronavirus (MERS-CoV) …
cycle of enveloped viruses. For Middle East respiratory syndrome coronavirus (MERS-CoV) …
[HTML][HTML] Physiological and molecular triggers for SARS-CoV membrane fusion and entry into host cells
JK Millet, GR Whittaker - Virology, 2018 - Elsevier
During viral entry, enveloped viruses require the fusion of their lipid envelope with host cell
membranes. For coronaviruses, this critical step is governed by the virally-encoded spike (S) …
membranes. For coronaviruses, this critical step is governed by the virally-encoded spike (S) …
Characterization of a highly conserved domain within the severe acute respiratory syndrome coronavirus spike protein S2 domain with characteristics of a viral fusion …
IG Madu, SL Roth, S Belouzard, GR Whittaker - Journal of virology, 2009 - Am Soc Microbiol
Many viral fusion proteins are primed by proteolytic cleavage near their fusion peptides.
While the coronavirus (CoV) spike (S) protein is known to be cleaved at the S1/S2 boundary …
While the coronavirus (CoV) spike (S) protein is known to be cleaved at the S1/S2 boundary …
[HTML][HTML] Unexpected receptor functional mimicry elucidates activation of coronavirus fusion
Recent outbreaks of severe acute respiratory syndrome and Middle East respiratory
syndrome, along with the threat of a future coronavirus-mediated pandemic, underscore the …
syndrome, along with the threat of a future coronavirus-mediated pandemic, underscore the …
[HTML][HTML] SARS-coronavirus spike S2 domain flanked by cysteine residues C822 and C833 is important for activation of membrane fusion
IG Madu, S Belouzard, GR Whittaker - Virology, 2009 - Elsevier
The S2 domain of the coronavirus spike (S) protein is known to be responsible for mediating
membrane fusion. In addition to a well-recognized cleavage site at the S1–S2 boundary, a …
membrane fusion. In addition to a well-recognized cleavage site at the S1–S2 boundary, a …
[HTML][HTML] Palmitoylation of SARS-CoV S protein is necessary for partitioning into detergent-resistant membranes and cell–cell fusion but not interaction with M protein
CE McBride, CE Machamer - Virology, 2010 - Elsevier
Coronaviruses are enveloped RNA viruses that generally cause mild disease in humans.
However, the recently emerged coronavirus that caused severe acute respiratory syndrome …
However, the recently emerged coronavirus that caused severe acute respiratory syndrome …
Structure of the fusion core and inhibition of fusion by a heptad repeat peptide derived from the S protein of Middle East respiratory syndrome coronavirus
J Gao, G Lu, J Qi, Y Li, Y Wu, Y Deng, H Geng… - Journal of …, 2013 - Am Soc Microbiol
Middle East respiratory syndrome coronavirus (MERS-CoV) recently emerged as a severe
worldwide public health concern. The virus is highly pathogenic, manifesting in infected …
worldwide public health concern. The virus is highly pathogenic, manifesting in infected …