Clinical Trials of Low‐Dose Carbon Monoxide

E Gomperts, A Gompertsd… - Carbon Monoxide in Drug …, 2022 - Wiley Online Library
The assessment of low‐dose carbon monoxide (CO) as a therapeutic in the clinic is unique
because of the diversity of data of the effects of low‐dose CO in humans. This chapter …

[图书][B] Carbon monoxide in drug discovery: basics, pharmacology, and therapeutic potential

B Wang, LE Otterbein - 2022 - books.google.com
CARBON MONOXIDE IN DRUG DISCOVERY An insightful reference for the latest
physiological and therapeutic studies of carbon monoxide In Carbon Monoxide in Drug …

Toward carbon monoxide–based therapeutics: Critical drug delivery and developability issues

X Ji, K Damera, Y Zheng, B Yu, LE Otterbein… - Journal of …, 2016 - Elsevier
Carbon monoxide (CO) is an intrinsic signaling molecule with importance on par with that of
nitric oxide. During the past decade, pharmacologic studies have amply demonstrated the …

The evolution of carbon monoxide into medicine

LE Otterbein - Respiratory care, 2009 - rc.rcjournal.com
The discovery that carbon monoxide (CO)—a highly publicized toxic gas molecule—can
have powerful benefits and curative effects not only changed how we view CO, but has, with …

Developing drug molecules for therapy with carbon monoxide

CC Romão, WA Blättler, JD Seixas… - Chemical Society …, 2012 - pubs.rsc.org
The use of Carbon Monoxide (CO) as a therapeutic agent has already been tested in human
clinical trials. Pre-clinically, CO gas administration proved beneficial in animal models of …

Towards “CO in a pill”: Pharmacokinetic studies of carbon monoxide prodrugs in mice

M Wang, X Yang, Z Pan, Y Wang, LK De La Cruz… - Journal of controlled …, 2020 - Elsevier
Carbon monoxide (CO) is a known endogenous signaling molecule with potential
therapeutic indications in treating inflammation, cancer, neuroprotection, and sickle cell …

[PDF][PDF] Biological and Pharmacological Properties of Carbon Monoxide: A General Overview. Oxygen 2022, 2, 130–151

A Bilska-Wilkosz, M Górny, M Iciek - 2022 - portalwiedzy.cm-uj.krakow.pl
Carbon monoxide (CO) is one of the most common causes of inhalation poisoning
worldwide. However, it is also well known that CO is produced endogenously in the heme …

Carbon monoxide and its role in human physiology: A brief historical perspective

K Kashfi, KK Patel - Biochemical Pharmacology, 2022 - Elsevier
Carbon monoxide is a molecule with notoriety in modern culture and extensive
documentation regarding its toxic physiological effects, long predating its formal discovery in …

Carbon monoxide and its controlled release: therapeutic application, detection, and development of carbon monoxide releasing molecules (CORMs) miniperspective

K Ling, F Men, WC Wang, YQ Zhou… - Journal of Medicinal …, 2017 - ACS Publications
Carbon monoxide (CO) is attracting increasing attention because of its role as a
gasotransmitter with cytoprotective and homeostatic properties. Carbon monoxide releasing …

Carbon monoxide signaling: Examining its engagement with various molecular targets in the context of binding affinity, concentration, and biologic response

Z Yuan, LK De La Cruz, X Yang, B Wang - Pharmacological Reviews, 2022 - ASPET
Carbon monoxide (CO) has been firmly established as an endogenous signaling molecule
with a variety of pathophysiological and pharmacological functions, including …