Although the phenotype of T-cell senescence has been extensively investigated, few studies
have analyzed the factors that promote the generation and maintenance of naïve and …

The progressive decline of the anatomical architecture and loss of functional integrity of an
individual is aging. Accumulation of degenerative cellular and molecular changes in the …

Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes
in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and …

It is now clear that access to specific metabolic programmes controls the survival and
function of various immune cell populations, including T cells. Efficient naïve and memory T …

Immunosenescence denotes a state of dysregulated immune cell function characterized by
a confluence of factors, including arrested cell cycle, telomere shortening, markers of cellular …

Aging is a time-dependent progressive physiological process, which results in impaired
immune system function. Age-related changes in immune function increase the susceptibility …

Aging is a complex phenomenon that causes the accumulation of cellular damage, leading
to an increased incidence of major age-related diseases such as cancer …

T cell survival, differentiation after stimulation, and function are intrinsically linked to distinct
cellular metabolic states. The ability of T cells to readily transition between metabolic states …

It is well known that aging is associated with dysregulated metabolism. This is seen both in
terms of systemic metabolism, as well as at the cellular level with clear mitochondrial …

T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and
cancer and in impairing the response to vaccination. Easy accessibility to peripheral human …