Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease and is
strongly associated with cardiovascular mortality. Given the pandemic of obesity and …

Despite remaining questions in this field, such as the specificity of currently available
ROCKi, or the roles of individual ROCK isoforms, recent evidence in experimental diabetes …

The small GTPase RhoA and its downstream effector, Rho kinase (ROCK), appear to
mediate numerous pathophysiological signals, including smooth muscle cell contraction …

Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine/threonine kinase
that was originally identified as RhoA interacting protein. A diverse array of cellular …

Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine/threonine kinase
with essential roles in cytoskeletal functions. Substantial evidence implicates ROCK as a …

Rho-associated, coiled-coil containing kinases (ROCK) were originally identified as effectors
of the RhoA small GTPase and found to belong to the AGC family of serine/threonine …

Small GTP ases of the R ho family and their down‐stream effectors R ho associated kinases
(ROCKs) are the molecules that converge a spectrum of pathophysiological signals …

Rho family GTPases have received increasing atten-tion as critical regulators of cell function
(1). Initially, they were shown to regulate actin dynamics, thereby modulating development …

OBJECTIVE—RhoA, a small GTPase protein, and its immediate downstream target, Rho
kinase (ROCK), control a wide variety of signal transduction pathways. Recent studies have …

Rho GTPases are a globular, monomeric group of small signaling G-protein molecules. Rho-
associated protein kinase/Rho-kinase (ROCK) is a downstream effector protein of the Rho …