Rho-associated kinases (ROCK) are activated in the kidney as well as in cultured cells of
diabetic models and have been implicated in renal pathophysiology. To explore whether …

Abstract The small GTPase Rho and its effector Rho-kinase (ROCK) are activated in the
diabetic kidney, and recent studies decade have demonstrated that ROCK signaling is an …

BACKGROUND AND PURPOSE The RhoA/Rho associated kinases (ROCK) pathway has
been implicated in the pathophysiology of diabetic nephropathy (DN). Early stages of …

Abstract The small GTPase Rho and its effector Rho kinase (ROCK) are involved in the
pathogenesis of diabetic kidney disease. Rho kinase has two isoforms: ROCK1 and ROCK2 …

Diabetic kidney disease (DKD) is the leading cause of kidney failure. RhoA/Rho-associated
protein kinase (ROCK) signaling is a recognized mediator of its pathogenesis, largely …

Dysregulation of fatty acid utilization is increasingly recognized as a significant component
of diabetic kidney disease. Rho-associated, coiled-coil–containing protein kinase (ROCK) is …

Diabetic kidney disease (DKD) stands as a pressing health challenge, with mesangial cell
fibrosis identified as a pivotal hallmark leading to glomerular sclerosis. Gaining a deeper …

In past decades, growing evidence from basic and clinical researches reveal that small
guanosine triphosphate binding protein ras homolog gene family, member A (RhoA) and its …

This review addresses the roles of Rho/Rho‐kinase (ROCK) pathway in the pathogenesis of
diabetes complications. Diabetes can cause many serious complications and can result in …

RhoA/Rho kinase: a novel therapeutic target in diabetic comp... : Chinese Medical Journal
RhoA/Rho kinase: a novel therapeutic target in diabetic complications : Chinese Medical Journal …