Rho-kinase (ROCK) is one of the downstream effectors of the small G-protein Rho. The Rho–
ROCK pathway has an important role in mediating various cellular functions, including …

Endothelial-to-mesenchymal transition (EndMT) can cause loss of tight junctions, which in
glomeruli are associated with albuminuria. Here we evaluated the role of EndMT in the …

Rho kinase (ROCK) belongs to the AGC (PKA/PKG/PKC) family of serine/threonine kinases
and is a major downstream effector of the small GTPase RhoA. ROCK plays central roles in …

The Rho/rho-kinase (ROCK) pathway has an important role in the pathogenesis of several
cardiovascular diseases. The activation of ROCK is involved in the regulation of vascular …

Rho kinase (ROCK) belongs to a family of Ser/Thr protein kinases that are activated via
interaction with the small GTP-binding protein RhoA. Growing evidence suggests that RhoA …

Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD), however,
specific treatment for DN has not yet been elucidated. Therefore, it is critically important to …

Background: Although blockade of Rho kinase with pharmacologic inhibitors ameliorates
renal fibrosis and diabetic kidney disease (DKD), the underlined mechanisms remain largely …

Arterial hypertension is a multifactorial disease that is characterised by increased peripheral
vascular resistance often accompanied by smooth muscle cell hypertrophy and proliferation …

The emerging critical implications of Rho/Rho-kinase (ROCK) signaling in
neurodegenerative diseases, glaucoma, renoprotection, diabetes and cancer have sparked …

Background The intracellular ROCK signaling pathway is an important modulator of blood
pressure and of cardiovascular and renal remodeling when Rho-kinase activity is increased …