Arterial hypertension is a common health problem that affects 25% of the adult population in
industrialized societies, and is a major risk factor for myocardial infarction and stroke …

Highlights•Rho kinase signaling plays important roles in the cardiovascular system.•Rho
kinase signaling mediates cardiac hypertrophy, apoptosis and fibrosis.•Rho kinase signaling …

ABSTRACT Introduction: The Rho-kinases (ROCK), ROCK1 and ROCK2, are potent,
widespread biochemical modulators which have been extensively studied. Due to the …

Non-specific inhibition of Rho-associated kinases (ROCKs) alleviated renal fibrosis in the
unilateral ureteral obstruction (UUO) model, while genetic deletion of ROCK1 did not affect …

Rho/Rho-kinase plays an important role in the regulation of vascular tone by enhancing
calcium sensitivity. 1 A growing body of evidence has indicated that activated Rho/Rho …

RhoA/Rho-kinase pathway plays an important role in many pathological conditions. RhoA
participates in the regulation of smooth muscle tone and activates many downstream …

ROCKs are important regulators of the actin cytoskeleton. Because changes in the actin
cytoskeleton underlie vascular contractility and remodeling, inflammatory cell recruitment …

Abstract Objectives Activation of RhoA/Rho-kinase (ROCK) is increasingly implicated in
acute vasospasm and chronic vasoconstriction in major organ systems. Therefore we aimed …

Rho-kinase (ROCK) is one of the effectors of the small GTP-binding protein Rho.
Accumulating evidence suggests that the Rho/ROCK system may play an important role in …

The small GTPase Rho is involved in cell-to-substratum adhesion and cell contraction.
These actions of Rho mediated by downstream Rho effectors such as Rho-associated coiled …