Regulation of HuR structure and function by dihydrotanshinone-I
P Lal, L Cerofolini, VG D'Agostino, C Zucal… - Nucleic acids …, 2017 - academic.oup.com
The Human antigen R protein (HuR) is an RNA-binding protein that recognizes U/AU-rich
elements in diverse RNAs through two RNA-recognition motifs, RRM1 and RRM2, and post …
elements in diverse RNAs through two RNA-recognition motifs, RRM1 and RRM2, and post …
The C-terminal RNA binding motif of HuR is a multi-functional domain leading to HuR oligomerization and binding to U-rich RNA targets
RM Scheiba, AI de Opakua, A Díaz-Quintana… - RNA biology, 2014 - Taylor & Francis
Human antigen R (HuR) is a 32 kDa protein with 3 RNA Recognition Motifs (RRMs), which
bind to Adenylate and uridylate Rich Elements (AREs) of mRNAs. Whereas the N-terminal …
bind to Adenylate and uridylate Rich Elements (AREs) of mRNAs. Whereas the N-terminal …
The structure of the ARE-binding domains of Hu antigen R (HuR) undergoes conformational changes during RNA binding
Human RNA-binding protein (HuR), a ubiquitously expressed member of the Hu protein
family, plays an important role in mRNA degradation and has been implicated as a key post …
family, plays an important role in mRNA degradation and has been implicated as a key post …
Identification and validation of novel small molecule disruptors of HuR-mRNA interaction
HuR, an RNA binding protein, binds to adenine-and uridine-rich elements (ARE) in the 3′-
untranslated region (UTR) of target mRNAs, regulating their stability and translation. HuR is …
untranslated region (UTR) of target mRNAs, regulating their stability and translation. HuR is …
Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function
Post-transcriptional regulation is an essential determinant of gene expression programs in
physiological and pathological conditions. HuR is a RNA-binding protein that orchestrates …
physiological and pathological conditions. HuR is a RNA-binding protein that orchestrates …
Targeting the multifaceted HuR protein, benefits and caveats
C Zucal, V D'Agostino, R Loffredo, B Mantelli… - Current drug …, 2015 - ingentaconnect.com
The RNA-binding protein (RBP) HuR is one of the most widely studied regulators of the
eukaryotic posttranscriptional gene expression and it plays a physiological role in mediating …
eukaryotic posttranscriptional gene expression and it plays a physiological role in mediating …
HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs
M Pabis, GM Popowicz, R Stehle… - Nucleic acids …, 2019 - academic.oup.com
HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that
acts primarily by stabilizing messenger RNA (mRNA) targets. HuR comprises three RNA …
acts primarily by stabilizing messenger RNA (mRNA) targets. HuR comprises three RNA …
The RNA binding protein HuR: a promising drug target for anticancer therapy
M Wu, CWS Tong, W Yan, KKW To… - Current cancer drug …, 2019 - ingentaconnect.com
The stability of mRNA is one of the key factors governing the regulation of eukaryotic gene
expression and function. Human antigen R (HuR) is an RNA-binding protein that regulates …
expression and function. Human antigen R (HuR) is an RNA-binding protein that regulates …
Small molecules targeting the RNA-binding protein HuR inhibit tumor growth in xenografts
The RNA-binding protein Hu antigen R (HuR) is a post-transcriptional regulator critical in
several types of diseases, including cancer, making it a promising therapeutic target. We …
several types of diseases, including cancer, making it a promising therapeutic target. We …
HuR as a molecular target for cancer therapeutics and immune-related disorders
M Majumder, P Chakraborty, S Mohan… - Advanced drug delivery …, 2022 - Elsevier
The control of eukaryotic gene expression occurs at multiple levels, from transcription to
messenger RNA processing, transport, localization, turnover, and translation. RNA-binding …
messenger RNA processing, transport, localization, turnover, and translation. RNA-binding …