Background Interleukin-1 receptor antagonist (IL1RN) variable number tandem repeats
(VNTRs) are not fully understood in Type 1 diabetes mellitus (T1DM). It may affect IL1RN …

Background: Genetic susceptibility has a crucial role in the development of type 1 diabetes
mellitus (T1DM). Several genes were found to be involved; one of the most important genes …

The interleukin-1α (IL-1α) gene appears to play a role in the pathogenesis of type 1 diabetes
(T1D). Therefore, the aim of this study was to investigate the contribution of the IL-1 …

Background: Type 2 diabetes mellitus (T2DM) is associated with a subclinical systemic
inflammation and development of complications like nephropathy, retinopathy, neuropathy …

Background Type-1 diabetes mellitus (T1DM) is a complex multifactorial disease with an
autoimmune etiology and is thought to result from an interaction between genetic and non …

ABSTRACT BACKGROUND: Inflammation is a key event closely associated with the
pathophysiology of type 2 diabetes mellitus (T2DM). Association of genetic polymorphisms …

Polymorphic variants at the interleukin-2 (IL2) locus affect the risk of several autoimmune
disorders. Our aim was to evaluate the association of the four IL2 polymorphisms …

The proinflammatory cytokine interleukin (IL)-1β is implicated in the development of insulin
resistance and β-cell dysfunction, whereas higher circulating levels of IL-1 receptor …

Abstract Background The polymorphism of Interleukin 1 receptor antagonist gene (IL-1RN),
which encodes a natural antagonist of pro-inflammatory cytokines belonging to IL-1 family …

ABSTRACT Background Type 1 diabetes (T1D) is a serious chronic autoimmune condition.
Even though the underlying reason for the onset of T1D is unknown, due to their effector and …