Chronic obstructive pulmonary disease (COPD) is a complex, heterogeneous, progressive
inflammatory airway disease associated with a significant impact on patients' lives, including …

The natural history of COPD is complex, and the disease is best understood as a syndrome
resulting from numerous interacting factors throughout the life cycle with smoking being the …

Chronic obstructive pulmonary disease (COPD) is a main global epidemic increasing as
population age and affecting approximately 10% of subjects over 45 years. COPD is a …

Inflammation in chronic obstructive pulmonary disease (COPD) is often corticosteroid
resistant and, thus, alternative anti-inflammatory approaches are needed. Since it is still not …

This chronic inflammatory change and repetitive injury from tobacco smoke and other
exposures propagate a cascade of events, including airway remodeling, that results in fixed …

Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent chronic
inflammatory diseases of the airways, with differences in etiology, pathogenesis …

There is an urgent need to develop more effective therapies for chronic obstructive
pulmonary disease (COPD) that target the underlying inflammatory disease process. Current …

Introduction In response to injury, epithelial cells release alarmins including thymic stromal
lymphopoietin (TSLP), high mobility group-box-1 (HMGB1), interleukin (IL)-33 and− 25 that …

Airway inflammation, driven by different types of inflammatory cells and mediators, plays a
fundamental role in COPD and its progression. Neutrophils, eosinophils, macrophages, and …

Chronic obstructive pulmonary disease (COPD) is a significant cause of morbidity and
mortality worldwide, and its prevalence is increasing. Airway inflammation is a consistent …