Myelination is essential for neuronal function and health. In peripheral nerves,> 100
causative mutations have been identified that cause Charcot-Marie-Tooth disease, a …

Schwann cell differentiation and myelination in the PNS are the result of fine-tuning of
positive and negative transcriptional regulators. As myelination starts, negative regulators …

Dicer is responsible for the generation of mature micro-RNAs (miRNAs) and loading them
into RNA-induced silencing complex (RISC). RISC functions as a probe that targets mRNAs …

Abstract Charcot–Marie–Tooth (CMT) neuropathies are a group of genetic disorders that
affect the peripheral nervous system with heterogeneous pathogenesis and no available …

Glial cells and neurons are engaged in a continuous and highly regulated bidirectional
dialog. A remarkable example is the control of myelination. Oligodendrocytes in the central …

Abstract Charcot–Marie–Tooth (CMT) neuropathies are highly heterogeneous disorders
caused by mutations in more than 70 genes, with no available treatment. Thus, it is difficult to …

Neddylation is a ubiquitylation-like pathway that controls cell cycle and proliferation by
covalently conjugating Nedd8 to specific targets. However, its role in neurons …

Dedifferentiation of myelinating Schwann cells is a key feature of nerve injury and
demyelinating neuropathies. We review recent evidence that this dedifferentiation depends …

CMT4D disease is a severe autosomal recessive demyelinating neuropathy with extensive
axonal loss leading to early disability, caused by mutations in the N-myc downstream …

Several key transcription factors and coregulators important to peripheral nerve myelination
have been identified, but the contributions of specific chromatin remodeling complexes to …