Migraine pathways and the identification of novel therapeutic targets

I Rainero, F Roveta, A Vacca, C Noviello… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction: Migraine is a chronic neurovascular disorder characterized by recurrent
headache attacks associated with neurological and autonomic symptoms. The …

[HTML][HTML] New insights on metabolic and genetic basis of migraine: novel impact on management and therapeutical approach

I Simonetta, R Riolo, F Todaro… - International Journal of …, 2022 - mdpi.com
Migraine is a hereditary disease, usually one-sided, sometimes bilateral. It is characterized
by moderate to severe pain, which worsens with physical activity and may be associated …

[HTML][HTML] Advances in understanding migraine pathophysiology: a bench to bedside review of research insights and therapeutics

K Frimpong-Manson, YT Ortiz, LR McMahon… - Frontiers in Molecular …, 2024 - frontiersin.org
The individual and global burden of migraine is of such significance that there are
accelerated efforts to develop new therapies. New migraine therapeutics are needed to …

Disentangling the intricacies of migraine: a review

P Girotra, S Kumar Singh, D Saini - CNS & Neurological …, 2014 - ingentaconnect.com
The etiology of migraine, a neurological disorder, has still not been clearly established,
although it may be categorized as a headache disorder with specific characteristics such as …

Current and novel insights into the neurophysiology of migraine and its implications for therapeutics

S Akerman, M Romero-Reyes, PR Holland - Pharmacology & Therapeutics, 2017 - Elsevier
Migraine headache and its associated symptoms have plagued humans for two millennia. It
is manifest throughout the world, and affects more than 1/6 of the global population. It is the …

Concepts of migraine headache pathogenesis: insights into mechanisms of chronicity and new drug targets

KMA Welch - Neurological Sciences, 2003 - Springer
The pathophysiology of migraine is incompletely understood. Neurobiological and gene
regulation studies and advanced brain imaging are providing new insights into migraine …

Novel therapeutic targets

P Geppetti, M Trevisani, P Nicoletti, JG Capone - Neurological Sciences, 2006 - Springer
The need for novel therapeutic strategies for the treatment of migraine and other primary
headaches is well recognised. Although the underlying mechanism (s) and the molecular …

[图书][B] Neurobiological basis of migraine

T Dalkara, MA Moskowitz - 2017 - books.google.com
Published with the New York Academy of Sciences A timely, broad-ranging exploration of
the neurobiological basis and molecular mechanisms of migraines Migraines impact the …

Recent advances in understanding migraine mechanisms, molecules and therapeutics

PJ Goadsby - Trends in molecular medicine, 2007 - cell.com
Migraine is a complex, disabling disorder of the brain that manifests itself as attacks of often
severe, throbbing head pain with sensory sensitivity to light, sound and head movement …

Chronic migraine: A process of dysmodulation and sensitization

M Su, S Yu - Molecular pain, 2018 - journals.sagepub.com
Chronic migraine is a common chronic daily headache featured by frequent headache
attacks with at least 15 headache days per month, which brings great disease burden to …