The development and use of antibacterial glycoconjugate vaccines have significantly
reduced the occurrence of potentially fatal childhood and adult diseases such as …

Glycoconjugate vaccines have provided enormous health benefits globally, but they have
been less successful in some populations at high risk for developing disease. To identify …

Currently licensed glycoconjugate vaccines are composed of a carbohydrate moiety
covalently linked to a protein carrier. Polysaccharides are T-cell independent antigens able …

Up to∼ 20% of HIV-infected individuals eventually develop broadly neutralizing antibodies
(bnAbs), and many of these antibodies (∼ 40%) target a region of dense high-mannose …

Coupling of carbohydrate antigens to protein carriers is a typical approach to enhancing the
immunogenicity of carbohydrate-based vaccines. Glycoconjugates with well-defined …

Vaccines targeting glycan structures at the surface of pathogenic microbes must overcome
the inherent T cell–independent nature of immune responses against glycans. Carbohydrate …

Vaccination is a key strategy for the control of various infectious diseases. Many pathogens,
such as Streptococcus pneumoniae, Haemophilus influenzae type b (Hib), and Neisseria …

Introduction: Globally, the three main pathogens causing serious infections are
Haemophilus influenzae type b, Streptococcus pneumoniae and Neisseria meningitidis …

Introduction: The global disease burden of serious bacterial infections is caused mainly by
Haemophilus influenzae type b (Hib), Streptococcus pneumoniae and Neisseria …

Glycoconjugate vaccines against bacteria are one of the success stories of modern
medicine and have led to a significant reduction in the global occurrence of bacterial …