The pathogenesis of Parkinson's disease (PD) is complex, multilayered, and not fully
understood, resulting in a lack of effective disease-modifying treatments for this prevalent …

Klotho is one of a number of well-known longevity-associated genes. Its depletion in aging
or disease may promote several neuropathologies associated with the central nervous …

Depression is a serious neuropsychiatric disease affecting an increasing number of people
worldwide. Cognitive deficits (including inattention, poor memory, and decision-making …

α-Klotho protein (KL) has been discovered more than 20 years ago, and immediately
emerged as a master regulator of agingrelated processes, which basically operates as an …

In this review we outline a rationale for identifying neuroprotectants aimed at inducing
endogenous Klotho activity and expression, which is epigenetic action, by definition. Such …

Abstract α-Klotho is known for its aging-related functions and is associated with
neurodegenerative diseases, accelerated aging, premature morbidity, and mortality. Recent …

Klotho is a hormone secreted into human cerebrospinal fluid (CSF), plasma and urine that
promotes longevity and influences the onset of several premature senescent phenotypes in …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder
characterized by the loss of motor neurons in the brain and spinal cord. ALS neuropathology …

The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed
in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened …

Parkinson's disease (PD) is a prevalent movement disorder in the elderly. PD is hallmarked
with progressive deterioration of mesencephalic dopaminergic neurons and development of …