Yersinia pestis is the causative agent of bubonic, pneumonic, and septicemic plague. We
demonstrate that Toll-like receptor 2-deficient (TLR2−/−) mice are resistant to septicemic …

We are using a systemic plague model to identify the cells and pathways that are
undermined by the virulence protein YopM of the plague bacterium Yersinia pestis. In this …

The virulence of the pathogenic Yersinia species depends on a plasmid-encoded type III
secretion system that transfers six Yop effector proteins into host cells. One of these proteins …

YopM, a protein toxin of Yersinia pestis, is necessary for virulence in a mouse model of
systemic plague. We previously reported YopM-dependent natural killer (NK) cell depletion …

Polymorphonuclear leukocytes, in addition to their direct bactericidal activities, produce
cytokines involved in the activation and regulation of the innate and adaptive immune …

YopM is required for full virulence of Yersinia pestis in systemic and bubonic plague, where
it functions to counteract innate defenses. Our lab has been using the systemic plague …

Abstract Although a Yersinia pseudotuberculosis (Yptb) lung infection model has been
developed to study Y. pestis pathogenesis, it is still necessary to establish a new animal …

Yersinia pestis, the etiologic agent of plague, delivers six Yersinia outer proteins (Yops) into
host cells upon direct bacterial contact. One of these, YopM, is necessary for virulence in a …

YopM is one of the six “effector Yops” of the human-pathogenic Yersinia, but its mechanism
has not been defined. After delivery to J774A. 1 monocyte-like cells, YopM can rapidly bind …

Yersinia pestis, the causative agent of plague, has been well studied at the molecular and
genetic levels, but little is known about the role that host genes play in combating this highly …