Early-life adversity and neurological disease: age-old questions and novel answers

AK Short, TZ Baram - Nature Reviews Neurology, 2019 - nature.com
Neurological illnesses, including cognitive impairment, memory decline and dementia, affect
over 50 million people worldwide, imposing a substantial burden on individuals and society …

Early life adversity shapes neural circuit function during sensitive postnatal developmental periods

L Malave, MT van Dijk, C Anacker - Translational psychiatry, 2022 - nature.com
Early life adversity (ELA) is a major risk factor for mental illness, but the neurobiological
mechanisms by which ELA increases the risk for future psychopathology are still poorly …

Early-life adversity and long-term neurobehavioral outcomes: epigenome as a bridge?

AM Vaiserman, AK Koliada - Human genomics, 2017 - Springer
Accumulating evidence suggests that adversities at critical periods in early life, both pre-and
postnatal, can lead to neuroendocrine perturbations, including hypothalamic-pituitary …

Early life adversity as a risk factor for cognitive impairment and Alzheimer's disease

Z Huang, JD Jordan, Q Zhang - Translational neurodegeneration, 2023 - Springer
Neurological conditions, including cognitive impairment and Alzheimer's disease (AD),
impose a huge burden on society, affecting millions of people globally. In addition to genetic …

Hazards to early development: the biological embedding of early life adversity

CA Nelson - Neuron, 2017 - cell.com
The number of children under 18 years of age has increased worldwide over the past
decade. This growth spurt is due, in part, to remarkable progress in child survival. Alas …

[HTML][HTML] Long-term neural embedding of childhood adversity in a population-representative birth cohort followed for 5 decades

MZ Gehred, AR Knodt, A Ambler, KJ Bourassa… - Biological …, 2021 - Elsevier
Background Childhood adversity has been previously associated with alterations in brain
structure, but heterogeneous designs, methods, and measures have contributed to mixed …

Early deprivation alters structural brain development from middle childhood to adolescence

MA Sheridan, CE Mukerji, M Wade, KL Humphreys… - Science …, 2022 - science.org
Hypotheses concerning the biologic embedding of early adversity via developmental
neuroplasticity mechanisms have been proposed on the basis of experimental studies in …

Early life exposure to unpredictable parental sensory signals shapes cognitive development across three species

EP Davis, K McCormack, H Arora, D Sharpe… - Frontiers in Behavioral …, 2022 - frontiersin.org
Exposure to early life adversity has long term consequences on cognitive function. Most
research has focused on understanding components of early life adversities that contribute …

Impact of early life adversities on human brain functioning: A coordinate-based meta-analysis

EJ Kraaijenvanger, TM Pollok, M Monninger… - Neuroscience & …, 2020 - Elsevier
The detrimental impact of early life adversities (ELAs; entailing pre-and postnatal
experiences) on the developing brain has been well established. By inducing neural …

[HTML][HTML] Broken or maladaptive? Altered trajectories in neuroinflammation and behavior after early life adversity

P Ganguly, HC Brenhouse - Developmental cognitive neuroscience, 2015 - Elsevier
Exposure to adversity and stress early in development yields vulnerability to mental
illnesses throughout the lifespan. Growing evidence suggests that this vulnerability has …